457081-03-7
457081-03-7
Chemical Structure
Pyridone 6
- CAS No.: 457081-03-7
- Formula:C18H16FN3O
- Molecular Weight:309.34
IUPAC Name: 2-(tert-butyl)-9-fluoro-1,6-dihydro-7H-benzo[h]imidazo[4,5-f]isoquinolin-7-one
InChIKey: VNDWQCSOSCCWIP-UHFFFAOYSA-N
SMILES: FC1=CC2=C(C(NC=C3)=O)C3=C(N=C(C(C)(C)C)N4)C4=C2C=C1
Biological Activity: Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC50s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pyridone 6 | 98.20% | Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC50s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases. | ||||||||||||||||||||
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Pyridone 6 (Standard) | ≥98% | Pyridone 6 (Standard) is the analytical standard of Pyridone 6. This product is intended for research and analytical applications. Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC50s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases. | ||||||||||||||||||||
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