1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. PF-03622905

PF-03622905 

Cat. No.: HY-139466
Handling Instructions

PF-03622905 is a potent and ATP-competitive PKC inhibitor with IC50s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, respectively. PF-03622905 shows high specificity for PKC over other protein kinases.

For research use only. We do not sell to patients.

PF-03622905 Chemical Structure

PF-03622905 Chemical Structure

CAS No. : 1072100-15-2

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Description

PF-03622905 is a potent and ATP-competitive PKC inhibitor with IC50s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, respectively. PF-03622905 shows high specificity for PKC over other protein kinases[1].

IC50 & Target[1]

PKCα

5.6 nM (IC50)

PKCβI

14.5 nM (IC50)

PKCβII

13 nM (IC50)

PKCγ

37.7 nM (IC50)

PKCθ

74.1 nM (IC50)

In Vitro

PF-03622905 causes concentration-dependent inhibition of phospho-ERK1/2 formation, interleukin 8 release, and phospho-SHP2 levels with an IC50 value 0.15 μM, 0.16 μM, and 35 nM, respectively[1].
PF-03622905 shows low cytotoxicity at 1 μM against human umbilical vein endothelial cells with remaining cell viability at 83.3% viable[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

469.58

Formula

C₂₄H₃₅N₇O₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PF-03622905
Cat. No.:
HY-139466
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