1072100-15-2
Chemical Structure
PF-03622905
- CAS No.: 1072100-15-2
- Formula:C24H35N7O3
- Molecular Weight:469.58
IUPAC Name: N-(5-((2S,5R)-5-(2-hydroxyethyl)-2-methyl-4-propylpiperazine-1-carbonyl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)picolinamide
InChIKey: SYMKCZOALSNIBQ-DLBZAZTESA-N
SMILES: O=C(C1=CC=CC=N1)NC2=NNC3=C2CN(C(N4C[C@H](N(C[C@@H]4C)CCC)CCO)=O)C3(C)C
Biological Activity: PF-03622905 is a potent and ATP-competitive PKC inhibitor with IC50s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, respectively. PF-03622905 shows high specificity for PKC over other protein kinases[1].
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PF-03622905 | PF-03622905 is a potent and ATP-competitive PKC inhibitor with IC50s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, respectively. PF-03622905 shows high specificity for PKC over other protein kinases. | |||||||||||||||||||||
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Keywords
