1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. PKC-theta inhibitor 1

PKC-theta inhibitor 1 

Cat. No.: HY-126328
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PKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM. PKC-theta inhibitor 1 demonstrates a reduction of symptoms in a mouse model of multiple sclerosis.

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PKC-theta inhibitor 1 Chemical Structure

PKC-theta inhibitor 1 Chemical Structure

CAS No. : 1160501-81-4

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Description

PKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM. PKC-theta inhibitor 1 demonstrates a reduction of symptoms in a mouse model of multiple sclerosis[1].

IC50 & Target[1]

PKCθ

6 nM (Ki)

PKCδ

392 μM (Ki)

PKCα

1020 μM (Ki)

IL-2 production

0.19 μM (IC50)

Molecular Weight

348.32

Formula

C₁₇H₁₅F₃N₄O

CAS No.

1160501-81-4

SMILES

NCC1(C2=CC=CC(C3=C4C(NN=C4C(F)(F)F)=NC=C3)=C2)COC1

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PKC-theta inhibitor 1
Cat. No.:
HY-126328
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