1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. PKC-theta inhibitor

PKC-theta inhibitor 

Cat. No.: HY-112681 Purity: 99.91%
Handling Instructions

PKC-theta inhibitor is a selective PKC-θinhibitor, with an IC50 of 12 nM.

For research use only. We do not sell to patients.

PKC-theta inhibitor Chemical Structure

PKC-theta inhibitor Chemical Structure

CAS No. : 736048-65-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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  • Technical Information

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Description

PKC-theta inhibitor is a selective PKC-θinhibitor, with an IC50 of 12 nM.

IC50 & Target

PKCθ

12 nM (IC50)

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (137.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2005 mL 11.0023 mL 22.0046 mL
5 mM 0.4401 mL 2.2005 mL 4.4009 mL
10 mM 0.2200 mL 1.1002 mL 2.2005 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

454.45

Formula

C₂₀H₂₅F₃N₆O₃

CAS No.

736048-65-0

SMILES

FC(F)(F)OC1=CC=CC=C1CNC2=NC=C([N+]([O-])=O)C(NCC3CCC(CN)CC3)=N2

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.91%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
PKC-theta inhibitor
Cat. No.:
HY-112681
Quantity:

PKC-theta inhibitor

Cat. No.: HY-112681