2. Neuronal Signaling Autophagy
  3. CaMK Autophagy
  4. CaMKII-IN-1

CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.

For research use only. We do not sell to patients.

CaMKII-IN-1 Chemical Structure

CaMKII-IN-1 Chemical Structure

CAS No. : 1208123-85-6

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 181 In-stock
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10 mg USD 220 In-stock
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Based on 2 publication(s) in Google Scholar

CaMKII-IN-1 Related Antibodies

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Description

CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC. IC50 value: 63 nM Target: CaMKII

Molecular Weight

548.10

Formula

C29H30ClN5O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(C1=CC=CC(Cl)=C1C)(NC2=C(CN(CC3=CC=CC=C3)CC4)C4=NC(NCCC5=CC=CC=C5)=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 54 mg/mL (98.52 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8245 mL 9.1224 mL 18.2448 mL
5 mM 0.3649 mL 1.8245 mL 3.6490 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8245 mL 9.1224 mL 18.2448 mL 45.6121 mL
5 mM 0.3649 mL 1.8245 mL 3.6490 mL 9.1224 mL
10 mM 0.1824 mL 0.9122 mL 1.8245 mL 4.5612 mL
15 mM 0.1216 mL 0.6082 mL 1.2163 mL 3.0408 mL
20 mM 0.0912 mL 0.4561 mL 0.9122 mL 2.2806 mL
25 mM 0.0730 mL 0.3649 mL 0.7298 mL 1.8245 mL
30 mM 0.0608 mL 0.3041 mL 0.6082 mL 1.5204 mL
40 mM 0.0456 mL 0.2281 mL 0.4561 mL 1.1403 mL
50 mM 0.0365 mL 0.1824 mL 0.3649 mL 0.9122 mL
60 mM 0.0304 mL 0.1520 mL 0.3041 mL 0.7602 mL
80 mM 0.0228 mL 0.1140 mL 0.2281 mL 0.5702 mL
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CaMKII-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CaMKII-IN-11208123-85-6CaMKAutophagyCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesInhibitorinhibitorinhibit

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