2. Neuronal Signaling
  3. CaMK
  4. CaMKII-IN-1

CaMKII-IN-1 is a highly selective inhibitor of CaMKII with an IC50 value of 63nM. It has almost no effect on CaMKIV, MLCK, p38a, Akt1, and PKC.

For research use only. We do not sell to patients.

CAS No. : 1208123-85-6

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Based on 5 publication(s) in Google Scholar

CaMKII-IN-1 Related Antibodies

Top Publications Citing Use of Products

    CaMKII-IN-1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 7;16(1):1429.  [Abstract]

    FACS analysis of CD8+ T-cell proliferation (CFSE low) in cultured with conditioned media derived from MC38 cells treated with WNT11 and inhibitors of CAMKII (CAMKII-IN-1)(100 nM), JNK (JNK-IN-8)(25 nM) and PKC (Go 6983)(100 nM) as indicated.

    View All CaMK Isoform Specific Products:

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    CaMK II CaMK III/eEF-2K CAMK IV PHK Trio DCAMKL

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    • Purity & Documentation

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    Description

    CaMKII-IN-1 is a highly selective inhibitor of CaMKII with an IC50 value of 63nM. It has almost no effect on CaMKIV, MLCK, p38a, Akt1, and PKC.

    IC50 & Target

    CaMK II

    63 nM (IC50)

    In Vitro

    CaMKII-IN-1 inhibits CaMKII with an IC50 value of 63 nM[1].
    CaMKII-IN-1 exhibits more than 100-fold higher selectivity for CaMKII over five types of off-target kinases (CaMKIV, MLCK, p38α, Akt1, PKC)[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    CaMKII-IN-1 Related Antibodies
    Molecular Weight

    548.10

    Formula

    C29H30ClN5O2S
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=S(C1=CC=CC(Cl)=C1C)(NC2=C(CN(CC3=CC=CC=C3)CC4)C4=NC(NCCC5=CC=CC=C5)=N2)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 54 mg/mL (98.52 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8245 mL 9.1224 mL 18.2448 mL
    5 mM 0.3649 mL 1.8245 mL 3.6490 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.8245 mL 9.1224 mL 18.2448 mL 45.6121 mL
    5 mM 0.3649 mL 1.8245 mL 3.6490 mL 9.1224 mL
    10 mM 0.1824 mL 0.9122 mL 1.8245 mL 4.5612 mL
    15 mM 0.1216 mL 0.6082 mL 1.2163 mL 3.0408 mL
    20 mM 0.0912 mL 0.4561 mL 0.9122 mL 2.2806 mL
    25 mM 0.0730 mL 0.3649 mL 0.7298 mL 1.8245 mL
    30 mM 0.0608 mL 0.3041 mL 0.6082 mL 1.5204 mL
    40 mM 0.0456 mL 0.2281 mL 0.4561 mL 1.1403 mL
    50 mM 0.0365 mL 0.1824 mL 0.3649 mL 0.9122 mL
    60 mM 0.0304 mL 0.1520 mL 0.3041 mL 0.7602 mL
    80 mM 0.0228 mL 0.1140 mL 0.2281 mL 0.5702 mL
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    CaMKII-IN-1 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    CaMKII-IN-11208123-85-6CaMKCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesInhibitorinhibitorinhibit

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