Vitamin K5 hydrochloride
Based on 1 Customer Validation
Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages.
For research use only. We do not sell to patients.
- Purity: 99.25%
- CAS No.: 130-24-5
- Formula: C11H12ClNO
- Molecular Weight:209.68
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Vitamin K5 (0-1600 μM) hydrochloride increases the antibacterial effects of UVA irradiation to Escherichia coli, Bacillus cereus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Klebsiella pneumoniae[1]. Vitamin K5 (250-1000 μM) hydrochloride generates superoxide anion radical and hydroxyl radical with a fixed UVA dose of 2.9 J cm-2[1]. Vitamin K5 (0-100 μM; 1 h) hydrochloride dose-dependently inhibits the cellular glucose consumption and lactate production[2]. Vitamin K5 hydrochloride dose-dependently suppresses the proliferation of colon 26 cells[3]. Vitamin K5 hydrochloride induces cell apoptosis and increases activity of caspase-3 in colon 26 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 130-24-5
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Appearance Solid
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Molecular Weight 209.68
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Formula C11H12ClNO
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Color Light yellow to light brown
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SMILES
OC1=C2C=CC=CC2=C(N)C=C1C.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 125 mg/mL (596.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Xu F, et al. Vitamin K5 is an efficient photosensitizer for ultraviolet A light inactivation of bacteria. FEMS Microbiol Lett. 2018 Feb 1;365(4). [Content Brief]
[2]. Chen J, et al. Vitamin K(3) and K(5) are inhibitors of tumor pyruvate kinase M2. Cancer Lett. 2012 Mar 28;316(2):204-10. [Content Brief]
[3]. Ogawa M, et al. Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells. Int J Oncol. 2007 Aug;31(2):323-31. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7693 mL | 23.8463 mL | 47.6926 mL | 119.2316 mL |
| 5 mM | 0.9539 mL | 4.7693 mL | 9.5385 mL | 23.8463 mL | |
| 10 mM | 0.4769 mL | 2.3846 mL | 4.7693 mL | 11.9232 mL | |
| 15 mM | 0.3180 mL | 1.5898 mL | 3.1795 mL | 7.9488 mL | |
| 20 mM | 0.2385 mL | 1.1923 mL | 2.3846 mL | 5.9616 mL | |
| 25 mM | 0.1908 mL | 0.9539 mL | 1.9077 mL | 4.7693 mL | |
| 30 mM | 0.1590 mL | 0.7949 mL | 1.5898 mL | 3.9744 mL | |
| 40 mM | 0.1192 mL | 0.5962 mL | 1.1923 mL | 2.9808 mL | |
| 50 mM | 0.0954 mL | 0.4769 mL | 0.9539 mL | 2.3846 mL | |
| 60 mM | 0.0795 mL | 0.3974 mL | 0.7949 mL | 1.9872 mL | |
| 80 mM | 0.0596 mL | 0.2981 mL | 0.5962 mL | 1.4904 mL | |
| 100 mM | 0.0477 mL | 0.2385 mL | 0.4769 mL | 1.1923 mL |
Vitamin K5 hydrochloride Related Classifications
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