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Vitamin K5  (Synonyms: Synkamin; Synkamin base)

Cat. No.: HY-B1814
Handling Instructions

Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages.

For research use only. We do not sell to patients.

Vitamin K5 Chemical Structure

Vitamin K5 Chemical Structure

CAS No. : 83-70-5

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Description

Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages[1][2][3].

IC50 & Target

IC50: 28 μM (PKM2), 191 μM PKM1, 120 μM (PKL)[2]

In Vitro

Vitamin K5 (0-1600 μmoL/L) increases the antibacterial effects of UVA irradiation to Escherichia coli, Bacillus cereus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Klebsiella pneumoniae[1].
Vitamin K5 (250-1000 μmoL/L) generates superoxide anion radical and hydroxyl radical with a fixed UVA dose of 2.9 J cm-2[1].
Vitamin K5 (0-100 μM; 1 h) dose-dependently inhibits the cellular glucose consumption and lactate production[2].
Vitamin K5 dose-dependently suppresses the proliferation of colon 26 cells[3].
Vitamin K5 induces cell apoptosis and increases activity of caspase-3 in colon 26 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

173.21

Formula

C11H11NO

CAS No.
SMILES

OC1=C2C=CC=CC2=C(N)C=C1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Vitamin K5
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HY-B1814
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