2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines
  6. MIP-1 beta/CCL4

MIP-1 beta/CCL4

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CCL4, also known as macrophage inflammatory protein (MIP-1β), belongs to the CC chemokine family and is a protein encoded in humans by the CCL4 gene, which belongs to the 17q11-q21 region of chromosome 17 and has a molecular weight of approximately 8-10 kDa. CCL4 can be produced by monocytes, B cells, T cells, NK cells, dendritic cells, neutrophils, fibroblasts, endothelial cells, and epithelial cells[1]. CCL4 acts as a chemokine that binds to the G protein-coupled receptors CCR5 and CCR8 and acts as a chemoattractant for natural killer cells, monocytes and various other immune cells at sites of inflammation or damaged tissues. In parallel, CCL4 can also act as a major HIV suppressor produced by CD8+ T cells, inducing dose-dependent inhibition of different strains of HIV-1, HIV-2 and monkey immunodeficiency virus (SIV). Among them, the N-terminal processed form CCL4 (3-69), produced by proteolytic cleavage of peripheral blood lymphocytes after secretion, retains the ability to induce down-regulation of chemokine receptor CCR5 surface expression and inhibit CCR5-mediated HIV-1 entry into T cells[2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7257
    CCL4 Protein, Human

    rHuMIP-1β/CCL4; C-C motif chemokine 4; LAG-1; Macrophage inflammatory protein 1-beta; SCYA4

    		Human E. coli
    CCL4 Protein, Human is a small cytokine of the CC chemokine subfamily that binds to the CCR5 chemokine receptor on the cell surface, promotes leukocyte aggregation under various inflammatory conditions, and contributes to immune protection against human immunodeficiency virus type 1. CCL4 Protein, Human is a recombinant human CCL4 (A24-N92) expressed by E. coli.
  • HY-P700165AF
    Animal-Free CCL4 Protein, Mouse (His)

    Ccl4; Mip1b; Scya4; C-C motif chemokine 4; Immune activation protein 2; ACT-2; ACT2; Macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4

    		Mouse E. coli
    CCL4 protein, with inflammatory and chemokinetic properties, acts as a monokine and self-associates to form homodimers. Animal-Free CCL4 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeCCL4 protein, expressed by E. coli, with N-His labeled tag. The total length of Animal-Free CCL4 Protein, Mouse (His) is 69 a.a., with molecular weight of ~8.64 kDa.
  • HY-P71889
    CCL4 Protein, Mouse

    Ccl4; Mip1b; Scya4; C-C motif chemokine 4; Immune activation protein 2; ACT-2; ACT2; Macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4

    		Mouse E. coli
    CCL4 protein, with inflammatory and chemokinetic properties, acts as a monokine and self-associates to form homodimers. CCL4 Protein, Mouse is the recombinant mouse-derived CCL4 protein, expressed by E. coli , with tag free. The total length of CCL4 Protein, Mouse is 69 a.a., with molecular weight of ~7.8 kDa.
  • HY-P71899
    CCL4 Protein, Rat

    Ccl4; Mip1b; Scya4C-C motif chemokine 4; Macrophage inflammatory protein 1-beta; MIP-1-beta; Small-inducible cytokine A4

    		Rat E. coli
    CCL4 protein, a monokine, acts as a homodimer and displays inflammatory and chemokinetic properties. CCL4 Protein, Rat is the recombinant rat-derived CCL4 protein, expressed by E. coli , with tag free. The total length of CCL4 Protein, Rat is 69 a.a., with molecular weight of ~11 kDa.
  • HY-P74342
    CCL4 Protein, Human (P.pastoris, His)

    MIP-1β/CCL4; C-C motif chemokine 4; LAG-1; SCYA4

    		Human P. pastoris
    CCL4 Protein, Human (P.pastoris, His) is a small cytokine of the CC chemokine subfamily that binds to the CCR5 chemokine receptor on the cell surface, promotes leukocyte aggregation under various inflammatory conditions, and contributes to immune protection against human immunodeficiency virus type 1. CCL4 Protein, Human (P.pastoris, His) is a recombinant human CCL4 (A24-Q92) expressed by P. pastoris with a His tag at the C-terminu.
Cat. No. Product Name Effect Purity