2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines
  6. CCL21

CCL21

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CCL21, also known as exodus-2 and secondary lymphoid chemokine (SLC), is a small cytokine belonging to the CC chemokine family and is located on chromosome 9 in the human genome. It binds to glycosaminoglycan (GAG) and is anchored to the surface of endothelial cells. As a chemokine, CCL21 inhibits hematopoiesis and stimulates chemotaxis, and is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages or neutrophils. At the same time, CCL21 is a potent stimulator of T cell migration and adhesion, binding to the glycoprotein PSGL-1 on T cells to promote the migration of T cells to secondary lymphoid organs. CCL21 can act through chemokine receptors CCR7 and CXCR3. Among them, CCR7 is a GPCR that is normally expressed by T cell subsets central memory cells, thymic T cells, B cells, mature DCs and other rare cell subsets. ccl21 can function as a microglia activator in the CNS and is expressed exclusively in endangered or mechanically damaged neurons[1][2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72875
    Exodus-2/CCL21 Protein, Human (sf9)

    C-C motif chemokine 21; Beta-chemokine exodus-2; 6Ckine; SLC; CCL21; SCYA21

    		Human Sf9 insect cells
    Exodus-2/CCL21 Protein, Human (sf9) is a homeostatic lymphoid chemokine that contributes to the entry of T cells and dendritic cells into the lymphoid T-zone. It acts through chemokine receptors CCR7 and CXCR3 to promote fibrogenic and inflammatory cytokine production. Exodus-2/CCL21 Protein, Human (sf9) is a recombinant human Exodus-2/CCL21 (S24-P134) expressed by Sf9 insect cells.
  • HY-P7166
    Exodus-2/CCL21 Protein, Human

    rHuExodus-2/CCL21; C-C motif chemokine 21; SLC; SCYA21

    		Human E. coli
    Exodus-2/CCL21 Protein, Human is a homeostatic lymphoid chemokine that contributes to the entry of T cells and dendritic cells into the lymphoid T-zone. It acts through chemokine receptors CCR7 and CXCR3 to promote fibrogenic and inflammatory cytokine production. Exodus-2/CCL21 Protein, Human  is a recombinant human Exodus-2/CCL21 (S24-P134) expressed by E. coli.
  • HY-P72756
    6Ckine/CCL21A Protein, Mouse

    C-C motif chemokine 21a; 6Ckine; TCA4; Ccl21a; Scya21; Scya21a

    		Mouse E. coli
    6Ckine/CCL21A Protein, Mouse is a homeostatic lymphoid chemokine that contributes to the entry of T cells and dendritic cells into the lymphoid T-zone. It acts through chemokine receptors CCR7 and CXCR3 to promote fibrogenic and inflammatory cytokine production. 6Ckine/CCL21 Protein, Mouse is a recombinant mouse 6Ckine/CCL21A (S24-G133) expressed by E. coli.
  • HY-P7167
    6Ckine/CCL21B Protein, Mouse

    6Ckine; CCL21B; Beta-chemokine exodus-2;

    		Mouse E. coli
    6Ckine/CCL21B Protein, Mouse is a homeostatic lymphoid chemokine that contributes to the entry of T cells and dendritic cells into the lymphoid T-zone. It acts through chemokine receptors CCR7 and CXCR3 to promote fibrogenic and inflammatory cytokine production. Exodus-2/CCL21 Protein, Mouse  is a recombinant mouse 6Ckine/CCL21B (S24-G133) expressed by E. coli.
  • HY-P75545
    6Ckine/CCL21A Protein, Mouse (sf9, His)

    C-C motif chemokine 21a; 6Ckine; TCA4; Ccl21a; Scya21; Scya21a

    		Mouse Sf9 insect cells
    6Ckine/CCL21A Protein, Mouse (sf9, His) is a homeostatic lymphoid chemokine that contributes to the entry of T cells and dendritic cells into the lymphoid T-zone. It acts through chemokine receptors CCR7 and CXCR3 to promote fibrogenic and inflammatory cytokine production. 6Ckine/CCL21 Protein, Mouse (sf9, His) is a recombinant mouse 6Ckine/CCL21A (S24-G133) expressed by Sf9 insect cells with a his tag at the C-terminus.
  • HY-P75546
    6Ckine/CCL21A Protein, Mouse (sf9)

    C-C motif chemokine 21a; 6Ckine; TCA4; Ccl21a; Scya21; Scya21a

    		Mouse Sf9 insect cells
    6Ckine/CCL21A Protein, Mouse (sf9) is a homeostatic lymphoid chemokine that contributes to the entry of T cells and dendritic cells into the lymphoid T-zone. It acts through chemokine receptors CCR7 and CXCR3 to promote fibrogenic and inflammatory cytokine production. 6Ckine/CCL21A Protein, Mouse (sf9) is a recombinant mouse 6Ckine/CCL21A (S24-G133) expressed by Sf9 insect cells.
  • HY-P76194
    6Ckine/CCL21 Protein, Rhesus Macaque (sf9)

    C-C motif chemokine 21; Beta-chemokine exodus-2; 6Ckine; SLC; CCL21; SCYA21

    		Rhesus Macaque Sf9 insect cells
    6Ckine/CCL21 Protein, Rhesus Macaque (sf9) is a homeostatic lymphoid chemokine that contributes to the entry of T cells and dendritic cells into the lymphoid T-zone. It acts through chemokine receptors CCR7 and CXCR3 to promote fibrogenic and inflammatory cytokine production. 6Ckine/CCL21 Protein, Rhesus Macaque (sf9) is a recombinant Rhesus Macaque  Exodus-2/CCL21 (M1-P131) expressed by Sf9 insect cells.
Cat. No. Product Name Effect Purity