1. Immunology/Inflammation
    Autophagy
  2. Toll-like Receptor (TLR)
    Autophagy
  3. Imiquimod hydrochloride

Imiquimod hydrochloride (Synonyms: R 837 hydrochloride)

Cat. No.: HY-B0180A Purity: 99.77%
Handling Instructions

Imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7agonist.

For research use only. We do not sell to patients.

Imiquimod hydrochloride Chemical Structure

Imiquimod hydrochloride Chemical Structure

CAS No. : 99011-78-6

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100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg USD 78 In-stock
Estimated Time of Arrival: December 31
500 mg USD 137 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Imiquimod hydrochloride:

Top Publications Citing Use of Products

Publications Citing Use of MCE Imiquimod hydrochloride

    Imiquimod hydrochloride purchased from MCE. Usage Cited in: Nat Commun. 2016 May 25;7:11724.

    Freshly prepared splenic B cells are left unstimulated (lanes 1 and 4), or stimulated by 10 μg/mL αIgM for 6 or 24 h (lanes 2 and 3), or by 1 μg/mL IMQ for 6, 24, 48 and 72 h (lanes 5-8), or by αIgM and IMQ for 24 or 48 h (lanes 9+10), respectively.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7agonist.

    IC50 & Target

    Toll-like receptor 7

    In Vivo

    In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].

    Clinical Trial
    Molecular Weight

    276.76

    Formula

    C₁₄H₁₇ClN₄

    CAS No.

    99011-78-6

    SMILES

    NC1=NC2=CC=CC=C2C3=C1N=CN3CC(C)C.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    Ethanol : 3.85 mg/mL (13.91 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6132 mL 18.0662 mL 36.1324 mL
    5 mM 0.7226 mL 3.6132 mL 7.2265 mL
    10 mM 0.3613 mL 1.8066 mL 3.6132 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.77%

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    Keywords:

    ImiquimodR 837R837R-837Toll-like Receptor (TLR)AutophagyInhibitorinhibitorinhibit

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    Product name:
    Imiquimod hydrochloride
    Cat. No.:
    HY-B0180A
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