1. Immunology/Inflammation
    Autophagy
    Anti-infection
  2. Toll-like Receptor (TLR)
    Autophagy
    SARS-CoV
    HSV
  3. Imiquimod hydrochloride

Imiquimod hydrochloride (Synonyms: R 837 hydrochloride)

Cat. No.: HY-B0180A Purity: 99.80%
Handling Instructions

Imiquimod hydrochloride (R 837 hydrochloride) is a selective toll like receptor 7 (TLR7) agonist acting as an immune response modifier. Imiquimod hydrochloride exhibits antiviral and antitumor effects in vivo. Imiquimod hydrochloride can be used for the research of external genital, perianal warts, cancer and COVID 19.

For research use only. We do not sell to patients.

Imiquimod hydrochloride Chemical Structure

Imiquimod hydrochloride Chemical Structure

CAS No. : 99011-78-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg USD 78 In-stock
Estimated Time of Arrival: December 31
500 mg USD 137 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Imiquimod hydrochloride:

Top Publications Citing Use of Products

    Imiquimod hydrochloride purchased from MCE. Usage Cited in: Nat Commun. 2016 May 25;7:11724.

    Freshly prepared splenic B cells are left unstimulated (lanes 1 and 4), or stimulated by 10 μg/mL αIgM for 6 or 24 h (lanes 2 and 3), or by 1 μg/mL IMQ for 6, 24, 48 and 72 h (lanes 5-8), or by αIgM and IMQ for 24 or 48 h (lanes 9+10), respectively.

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    Description

    Imiquimod hydrochloride (R 837 hydrochloride) is a selective toll like receptor 7 (TLR7) agonist acting as an immune response modifier. Imiquimod hydrochloride exhibits antiviral and antitumor effects in vivo. Imiquimod hydrochloride can be used for the research of external genital, perianal warts, cancer and COVID 19[1][2].

    IC50 & Target[1][3]

    TLR7

     

    HSV-1

     

    In Vivo

    In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    276.76

    Formula

    C₁₄H₁₇ClN₄

    CAS No.

    99011-78-6

    SMILES

    NC1=NC2=CC=CC=C2C3=C1N=CN3CC(C)C.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    Methanol : 24 mg/mL (86.72 mM; Need ultrasonic)

    DMSO : 8 mg/mL (28.91 mM; ultrasonic and warming and heat to 50°C)

    Ethanol : 3.85 mg/mL (13.91 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6132 mL 18.0662 mL 36.1324 mL
    5 mM 0.7226 mL 3.6132 mL 7.2265 mL
    10 mM 0.3613 mL 1.8066 mL 3.6132 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 0.8 mg/mL (2.89 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 0.8 mg/mL (2.89 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 0.8 mg/mL (2.89 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.80%

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    Keywords:

    ImiquimodR 837R837R-837Toll-like Receptor (TLR)AutophagySARS-CoVHSVSARS coronavirusHerpes simplex virushumanpapillomaviruswartsmolluscumcontagiosumactinickeratosisbasal ,cellcarcinomasquamouscellBowen'sdiseasenongenitalinfectionvulvarintraepithelialneoplasiaInhibitorinhibitorinhibit

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    Product Name:
    Imiquimod hydrochloride
    Cat. No.:
    HY-B0180A
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