1. Immunology/Inflammation
    Autophagy
  2. Toll-like Receptor (TLR)
    Autophagy
  3. Imiquimod maleate

Imiquimod maleate (Synonyms: R 837 maleate)

Cat. No.: HY-B0180B
Handling Instructions

Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7agonist.

For research use only. We do not sell to patients.

Imiquimod maleate Chemical Structure

Imiquimod maleate Chemical Structure

CAS No. : 896106-16-4

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Top Publications Citing Use of Products

Publications Citing Use of MCE Imiquimod maleate

    Imiquimod maleate purchased from MCE. Usage Cited in: Nat Commun. 2016 May 25;7:11724.

    Freshly prepared splenic B cells are left unstimulated (lanes 1 and 4), or stimulated by 10 μg/mL αIgM for 6 or 24 h (lanes 2 and 3), or by 1 μg/mL IMQ for 6, 24, 48 and 72 h (lanes 5-8), or by αIgM and IMQ for 24 or 48 h (lanes 9+10), respectively.
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    Description

    Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7agonist.

    IC50 & Target

    Toll-like receptor 7

    In Vivo

    In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].

    Clinical Trial
    Molecular Weight

    356.38

    Formula

    C₁₈H₂₀N₄O₄

    CAS No.

    896106-16-4

    SMILES

    NC1=NC2=CC=CC=C2C3=C1N=CN3CC(C)C.O=C(O)/C=C\C(O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Keywords:

    ImiquimodR 837R837R-837Toll-like Receptor (TLR)AutophagyInhibitorinhibitorinhibit

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    Imiquimod maleate
    Cat. No.:
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