1. Immunology/Inflammation
    Autophagy
    Anti-infection
  2. Toll-like Receptor (TLR)
    Autophagy
    SARS-CoV
    HSV
  3. Imiquimod maleate

Imiquimod maleate (Synonyms: R 837 maleate)

Cat. No.: HY-B0180B
Handling Instructions

Imiquimod maleate (R 837 maleate) is a selective toll like receptor 7 (TLR7) agonist acting as an immune response modifier. Imiquimod maleate exhibits antiviral and antitumor effects in vivo. Imiquimod maleate can be used for the research of external genital, perianal warts, cancer and COVID 19.

For research use only. We do not sell to patients.

Imiquimod maleate Chemical Structure

Imiquimod maleate Chemical Structure

CAS No. : 896106-16-4

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Top Publications Citing Use of Products

    Imiquimod maleate purchased from MCE. Usage Cited in: Nat Commun. 2016 May 25;7:11724.

    Freshly prepared splenic B cells are left unstimulated (lanes 1 and 4), or stimulated by 10 μg/mL αIgM for 6 or 24 h (lanes 2 and 3), or by 1 μg/mL IMQ for 6, 24, 48 and 72 h (lanes 5-8), or by αIgM and IMQ for 24 or 48 h (lanes 9+10), respectively.

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    Description

    Imiquimod maleate (R 837 maleate) is a selective toll like receptor 7 (TLR7) agonist acting as an immune response modifier. Imiquimod maleate exhibits antiviral and antitumor effects in vivo. Imiquimod maleate can be used for the research of external genital, perianal warts, cancer and COVID 19[1][2].

    IC50 & Target[1][3]

    TLR7

     

    HSV-1

     

    In Vivo

    In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    356.38

    Formula

    C₁₈H₂₀N₄O₄

    CAS No.

    896106-16-4

    SMILES

    NC1=NC2=CC=CC=C2C3=C1N=CN3CC(C)C.O=C(O)/C=C\C(O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Keywords:

    ImiquimodR 837R837R-837Toll-like Receptor (TLR)AutophagySARS-CoVHSVSARS coronavirusHerpes simplex virushumanpapillomaviruswartsmolluscumcontagiosumactinickeratosisbasal ,cellcarcinomasquamouscellBowen'sdiseasenongenitalinfectionvulvarintraepithelialneoplasiaInhibitorinhibitorinhibit

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    Imiquimod maleate
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