LDLRAP1-IN-1
LDLRAP1-IN-1 (Compound B19) is a LDLRAP1 inhibitor and antiviral agent, with an IC50 of 4.98 μM for disrupting the interaction between LDLRAP1 and LDLR. LDLRAP1-IN-1 covalently modifies the C119 residue of LDLRAP1 at the LDLRAP1-LDLR binding interface, thereby disrupting the interaction between LDLRAP1 and LDLR. LDLRAP1-IN-1 exhibits antiviral activity against HCoV-OC43.
For research use only. We do not sell to patients.
- CAS No.: 3093624-24-6
- Formula: C21H14ClN5O4
- Molecular Weight:435.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
LDLRAP1-IN-1 (5 days potently inhibits HCoV-OC43 infection in Vero E6 cells with an EC50 of 1.0 ± 0.1 μM, while exhibiting low cytotoxicity (CC50 = 151 μM)[1].
LDLRAP1-IN-1 (1 h) disrupts the interaction between LDLRAP1 and LDLR, with an IC50 of 4.98 μM, and reduces the binding affinity by 11.1-fold[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3093624-24-6
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Molecular Weight 435.82
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Formula C21H14ClN5O4
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SMILES
O=C(NC1=CC=C(N2N=CN=C2)C=C1)C3=CC([N+]([O-])=O)=CC=C3OC4=CC=C(Cl)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LDLRAP1-IN-1 Related Classifications
HY-181997 Related Classifications
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