1. Apoptosis Metabolic Enzyme/Protease Anti-infection
  2. Apoptosis MMP HIV HIV Protease SARS-CoV
  3. Indinavir sulfate ethanolate

Indinavir sulfate ethanolate  (Synonyms: MK-639 ethanolate; L735524 ethanolate)

Cat. No.: HY-B0689B
Handling Instructions

Indinavir sulfate ethanolate (MK-639 ethanolate) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate ethanolate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate ethanolate is also a SARS-CoV 3CLpro inhibitor.

For research use only. We do not sell to patients.

Indinavir sulfate ethanolate Chemical Structure

Indinavir sulfate ethanolate Chemical Structure

CAS No. : 2563866-80-6

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Description

Indinavir sulfate ethanolate (MK-639 ethanolate) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate ethanolate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate ethanolate is also a SARS-CoV 3CLpro inhibitor[1][2][3][4].

IC50 & Target

HIV-1

 

MMP-2

 

In Vitro

Indinavir sulfate ethanolate (0-50 µM; 18 h) blocks lymphocyte cell cycle in G0/G1 phase in PBMCs cells and impairs lymphoproliferative responses[1].
Indinavir sulfate ethanolate (40 µM-40 nM; 5 days) inhibits cell invasion and (40 µM-40 nM; 48 h) MMPs-2 activation of the Huh7 and SK-HEP-1 hepatocarcinoma cells in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PBMCs (from healthy and HIV-infected volunteers)
Concentration: 0-50 µM
Incubation Time: 18 h (pretreatment; stimulation with anti-CD3 for an additional 48 hours)
Result: Blocked anti-CD3-induced cell-cycle progression in a dose-dependent manner.
Resulted in dose-dependent reduction of lymphoproliferative responses.

Cell Invasion Assay[2]

Cell Line: Huh7 and SK-HEP-1 cells
Concentration: 40 µM-40 nM
Incubation Time: 5 days
Result: Reduced ability to invade an in vitro constituted extracellular matrix for both cell lines treated compared with the untreated cells.

Western Blot Analysis[2]

Cell Line: Huh7 and SK-HEP-1 cells
Concentration: 40 µM-40 nM
Incubation Time: 48 h
Result: Blocked the conversion of latent MMP-2 to its 62/64-kDa active form.
In Vivo

Indinavir sulfate ethanolate (70 mg/kg; i.g.; once a day for 3 weeks) inhibits the growth of hepatocarcinoma cells in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice(s.c. into Huh7 and SK-HEP-1 cells)[2].
Dosage: 70 mg/kg
Administration: Oral gavage; once a day for 3 weeks
Result: Delaied the growth of s.c. implanted hepatocarcinoma xenografts in nude mice compared with placebo.
Clinical Trial
Molecular Weight

757.94

Formula

C38H55N5O9S

CAS No.
SMILES

CCO.O=C([C@@H](C[C@H](O)CN(CCN(CC1=CN=CC=C1)C2)[C@@H]2C(NC(C)(C)C)=O)CC3=CC=CC=C3)N[C@H]4C(C=CC=C5)=C5C[C@H]4O.O=S(O)(O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Indinavir sulfate ethanolate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Indinavir sulfate ethanolate
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HY-B0689B
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