HIV Reverse Transcriptase

HIV reverse transcriptase is a crucial enzyme encoded by the retroviral genome that catalyzes the conversion of viral RNA into double-stranded proviral DNA, enabling integration into the host cell's genome. As an RNA-dependent DNA polymerase, it synthesizes a DNA-RNA hybrid using the viral RNA as a template, followed by degradation of the RNA strand by RNase H and replacement with DNA to form a double-stranded DNA molecule. This proviral DNA can then integrate into the host chromosome, becoming a permanent part of the host's genetic material and serving as a template for viral mRNA production. The enzyme lacks proofreading ability due to the absence of 3′ to 5′ exonuclease activity, resulting in a high mutation rate that contributes to the genetic diversity and adaptability of HIV, facilitating immune evasion and resistance to antiretroviral drugs.
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  • HIV Reverse Transcriptase (2)

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(-)-Calanolide B
(-)-Calanolide B
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Cat. No.: HY-N19744
CAS No.: 909-14-8
  • Formula: C22H26O5
  • Molecular Weight: 370.44

(-)-Calanolide B is a non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC50 of 0.5 mM against HIV-1 RT. (-)-Calanolide B inhibits the replication of HIV-1 IIIb/LAV. (-)-Calanolide B is applicable to research related to HIV-1 infection.

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R-95845
R-95845
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Cat. No.: HY-187616
CAS No.: 163435-77-6
  • Formula: C17H16Br2N2O2
  • Molecular Weight: 440.14

R-95845 is a non-nucleoside HIV-1 reverse transcriptase (RT) inhibitor. R-95845 is specific to HIV-1 RT and acts as a functionally non-competitive inhibitor with respect to nucleotide incorporation. R-95845 binds to the non-nucleoside inhibitor binding pocket of HIV-1 RT in a butterfly-like conformation, forms hydrogen bonds with Tyr 188 and Val 189, and engages in hydrophobic interactions with surrounding residues. R-95845 can be used in studies related to HIV-1 infection and acquired immunodeficiency syndrome.

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