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Cat. No.: HY-N19744

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(-)-Calanolide B

(-)-Calanolide B is a non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC₅₀ of 0.5 mM against HIV-1 RT. (-)-Calanolide B inhibits the replication of HIV-1 IIIb/LAV. (-)-Calanolide B is applicable to research related to HIV-1 infection.

For research use only. We do not sell to patients.

CAS No.: 909-14-8
Formula: C₂₂H₂₆O₅
Molecular Weight:370.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(-)-Calanolide B Chemical Structure

CAS No.: 909-14-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

IC₅₀ & Target

^[1]

HIV-1 RT

0.5 mM (IC₅₀)

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	18.7 μM Compound: (-)-1	Anti-HIV activity against HIV-I RFII strain in CEM cell line Anti-HIV activity against HIV-I RFII strain in CEM cell line	[PMID: 8632437]
CEM-SS	EC₅₀	0.2 μM Compound: 2	Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	IC₅₀	5.9 μM Compound: 2	Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	EC₅₀	0.2 μM Compound: (-)-Calanolide B	Antiviral activity against HIV1 RF in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against HIV1 RF in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect	[PMID: 11430019]
H9	EC₅₀	0.22 μM Compound: 13	Antiviral activity against HIV1 infected in human H9 cells assessed as effect on virus-induced cytopathic effect by tetrazolium/formazan assay Antiviral activity against HIV1 infected in human H9 cells assessed as effect on virus-induced cytopathic effect by tetrazolium/formazan assay	[PMID: 8792623]
H9	IC₅₀	9.8 μM Compound: 13	Cytotoxicity against human H9 cells Cytotoxicity against human H9 cells	[PMID: 8792623]
MT2	IC₅₀	5.89 μM Compound: (-)-1	Anti-HIV activity against HIV-I A17 strain in MT2 cell line Anti-HIV activity against HIV-I A17 strain in MT2 cell line	[PMID: 8632437]
MT2	IC₅₀	6.16 μM Compound: (-)-1	Anti-HIV activity against HIV-I G910-6 strain in MT2 cell line Anti-HIV activity against HIV-I G910-6 strain in MT2 cell line	[PMID: 8632437]
MT2	IC₅₀	6.21 μM Compound: (-)-1	Anti-HIV activity against HIV-I H112-2 strain in MT2 cell line Anti-HIV activity against HIV-I H112-2 strain in MT2 cell line	[PMID: 8632437]
MT2	IC₅₀	7.31 μM Compound: (-)-1	Anti-HIV activity against HIV-I IIIB strain in MT2 cell line Anti-HIV activity against HIV-I IIIB strain in MT2 cell line	[PMID: 8632437]

In Vitro

(-)-Calanolide B (Compound 7) at 1 mM potently inhibits HIV-1 RT, with an IC₅₀ of 0.5 mM and an inhibition rate of 76.2% at 1 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 909-14-8
Molecular Weight 370.44
Formula C₂₂H₂₆O₅
SMILES

CCCC(C1=C(O2)C3=C(O[C@H]([C@@H]([C@@H]3O)C)C)C4=C1OC(C)(C=C4)C)=CC2=O
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huerta-Reyes M, Basualdo Mdel C, Abe F, et al.. HIV-1 inhibitory compounds from Calophyllum brasiliense leaves. Biological & pharmaceutical bulletin. 2004 Sep;27(9):1471-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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