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Cat. No.: HY-N19744

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(-)-Calanolide B

(-)-Calanolide B is a non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC₅₀ of 0.5 mM against HIV-1 RT. (-)-Calanolide B inhibits the replication of HIV-1 IIIb/LAV. (-)-Calanolide B is applicable to research related to HIV-1 infection.

For research use only. We do not sell to patients.

CAS No.: 909-14-8
Formula: C₂₂H₂₆O₅
Molecular Weight:370.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(-)-Calanolide B Chemical Structure

CAS No.: 909-14-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HIV-1 RT

0.5 mM (IC₅₀)

All HIV Isoforms :

In Vitro

(-)-Calanolide B (Compound 7) at 1 mM potently inhibits HIV-1 RT, with an IC₅₀ of 0.5 mM and an inhibition rate of 76.2% at 1 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 909-14-8
Molecular Weight 370.44
Formula C₂₂H₂₆O₅
SMILES

CCCC(C1=C(O2)C3=C(O[C@H]([C@@H]([C@@H]3O)C)C)C4=C1OC(C)(C=C4)C)=CC2=O
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huerta-Reyes M, Basualdo Mdel C, Abe F, et al.. HIV-1 inhibitory compounds from Calophyllum brasiliense leaves. Biological & pharmaceutical bulletin. 2004 Sep;27(9):1471-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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(-)-Calanolide B

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(-)-Calanolide B Related Classifications

HY-N19744 Related Classifications