2091134-68-6
2091134-68-6
Chemical Structure
Golidocitinib
Synonym(s): AZD4205
- CAS No.: 2091134-68-6
- Formula:C25H31N9O2
- Molecular Weight:489.57
IUPAC Name: (R)-N-(3-(2-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-1H-indol-7-yl)-2-(4-methylpiperazin-1-yl)propanamide
InChIKey: CVCVOSPZEVINRM-MRXNPFEDSA-N
SMILES: C[C@@H](N1CCN(C)CC1)C(NC2=C3C(C(C4=NC(NC5=CN(C)N=C5OC)=NC=C4)=CN3)=CC=C2)=O
Biological Activity: Golidocitinib (AZD4205) is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Golidocitinib | 99.54% | Golidocitinib (AZD4205) is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM). | ||||||||||||||||||||
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Golidocitinib (Standard) | Golidocitinib (Standard) (AZD4205 (Standard)) is the analytical standard of Golidocitinib (HY-107361). This product is intended for research and analytical applications. Golidocitinib (AZD4205) is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM). | |||||||||||||||||||||
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