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Ptpn2 - protein tyrosine phosphatase, non-receptor type 2 Gene

Also Known as Ptpt; TC-PTP

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19255

Summary

Enables STAT family protein binding activity and protein tyrosine Phosphatase activity. Involved in several processes, including hemopoiesis; negative regulation of signal transduction; and positive regulation of response to endoplasmic reticulum stress. Acts upstream of or within Insulin Receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in nucleus. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; lower jaw; and midbrain. Orthologous to human PTPN2 (protein tyrosine Phosphatase non-receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn2 Products (2)

mRNA	Protein	Name
NM_001127177.1	NP_001120649.1	tyrosine-protein phosphatase non-receptor type 2 isoform b
NM_008977.3	NP_033003.1	tyrosine-protein phosphatase non-receptor type 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables STAT family protein binding	IPI IPI: Inferred from physical interaction	26026268	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16705167	MGI
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	15632081	MGI
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	14966296	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	9271584	MGI
involved in T cell differentiation	IMP IMP: Inferred from mutant phenotype	9271584	MGI
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	9271584	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	20484139	MGI
involved in insulin receptor recycling	IDA IDA: Inferred from direct assay	15632081	MGI
acts upstream of or within insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15632081	MGI
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	15696169	MGI
involved in negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22080863	MGI
involved in negative regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	14966296	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	14726372	MGI
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12612081	MGI
involved in negative regulation of interleukin-2-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11909529	MGI
involved in negative regulation of interleukin-4-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	17210636	MGI
involved in negative regulation of interleukin-6-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20484139	MGI
involved in negative regulation of lipid storage	IMP IMP: Inferred from mutant phenotype	20484139	MGI
involved in negative regulation of macrophage colony-stimulating factor signaling pathway	IMP IMP: Inferred from mutant phenotype	16705167	MGI
involved in negative regulation of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	16705167	MGI
involved in negative regulation of platelet-derived growth factor receptor-beta signaling pathway	IMP IMP: Inferred from mutant phenotype	14966296	MGI
involved in negative regulation of positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	22080863	MGI
involved in negative regulation of protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	21216966	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IPI IPI: Inferred from physical interaction	26026268	MGI
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	15696169	MGI
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11909529	MGI
involved in negative regulation of type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12138178	MGI
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	14966296	MGI
involved in positive regulation of PERK-mediated unfolded protein response	IMP IMP: Inferred from mutant phenotype	21216966	MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21216966	MGI
involved in positive regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	20484139	MGI
acts upstream of or within protein dephosphorylation	IDA IDA: Inferred from direct assay	26026268	MGI
acts upstream of or within protein dephosphorylation	IGI IGI: Inferred from genetic interaction	26026268	MGI
acts upstream of or within protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	15632081	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in endosome lumen	IDA IDA: Inferred from direct assay	12612081	MGI
located in nucleus	IDA IDA: Inferred from direct assay	21216966	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type 2	MPTP T cell protein-tyrosine phosphatase protein-tyrosine phosphatase PTP-2

Recombinant Ptpn2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76669	TCPTP Protein, Mouse (sf9, His)	Q06180 (S2-N314)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145923	Osunprotafib	Inhibitor	99.43%	Phase 1

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148691	PROTAC PTPN2 degrader-1	Degrader	/	Unkown
HY-153446	Tegeprotafib	Inhibitor	99.30%	Unkown
HY-162428	PTPN2/1-IN-3	Inhibitor	99.89%	Unkown
HY-149760	PVD-06	Inhibitor	98.30%	Unkown
HY-153638	PTPN2/1-IN-2	Antagonist	99.56%	Unkown
HY-RS11421	PTPN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-145923B	Osunprotafib hydrochloride	Inhibitor	/	Unkown
HY-153938	PROTAC PTPN2 degrader-2		/	Unkown
HY-153938A	PROTAC PTPN2 degrader-2 TFA		/	Unkown
HY-156606	Anticancer agent 142	Inhibitor	/	Unkown
HY-156607	Anticancer agent 143	Inhibitor	/	Unkown
HY-156608	Anticancer agent 144	Inhibitor	/	Unkown
HY-163596	PTPN2-IN-1	Inhibitor	/	Unkown
HY-168691	PTPN2 ligand 1	Ligand	/	Unkown
HY-175618	PTPN2 ligand 2	Ligand	/	Unkown
HY-175619	PTPN2 ligand-Linker Conjugate 1	Ligand	/	Unkown
HY-178716	PTPN2/1-IN-4		/	Unkown
HY-179380	PTPN2-IN-2		/	Unkown
HY-181255	PTPN2-IN-3	Inhibitor	/	Unkown
HY-183937A	PD-305		/	Unkown
HY-184259	PTPN2 ligand 4	Degrader	/	Unkown
HY-W585105	PTPN2 ligand 3	Ligand	/	Unkown
HY-W733139	3-[2-Oxo-6-(4-Pip)-Bz[cd]indol-1-yl]-Pip-2,6-dione		/	Unkown
HY-RS16588	Ptpn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23023	Ptpn2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptpn2	NCBI	NCBI:5771