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Cat. No.: HY-184259

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PTPN2 ligand 4

PTPN2 ligand 4 is a PTPN2 ligand and can be used for the synthesis of PROTACs, such as PD-305 (HY-183937).

For research use only. We do not sell to patients.

Formula: C₁₅H₁₆FN₃O₄S
Molecular Weight:353.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PTPN2 ligand 4 Chemical Structure

Size

Price

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Quantity

Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

PTPN2 ligand 4 is a PTPN2 ligand and can be used for the synthesis of PROTACs, such as PD-305 (HY-183937)^[1].

IC₅₀ & Target^[1]

PTPN2

Chemical Information

Molecular Weight 353.37
Formula C₁₅H₁₆FN₃O₄S
SMILES

FC1=C(N2CC(NS2(=O)=O)=O)C(O)=CC(C)=C1C#CC3CCNC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hu L, et al. Discovery of Novel Alkynylbenzene Scaffold-Based PTPN2-Selective Degrader PD-305 with Exceptional Potency and In Vivo Efficacy. J Med Chem. 2026;69(10):11998-12019. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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