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Cat. No.: HY-184258

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CRBN ligand-905

CRBN ligand-905 is a CRBN ligand and can be used for the synthesis of PROTACs, such as PD-305 (HY-183937).

For research use only. We do not sell to patients.

CAS No.: 2504233-60-5
Formula: C₁₆H₁₂N₂O₃
Molecular Weight:280.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CRBN ligand-905 Chemical Structure

CAS No.: 2504233-60-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
Chemical Information
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Description

CRBN ligand-905 is a CRBN ligand and can be used for the synthesis of PROTACs, such as PD-305 (HY-183937)^[1].

IC₅₀ & Target^[1]

Cereblon

All Ligands for E3 Ligase Isoforms :

Chemical Information

CAS No. 2504233-60-5
Molecular Weight 280.28
Formula C₁₆H₁₂N₂O₃
SMILES

O=C(C(CC1)N2C3=C4C(C=CC=C4C2=O)=CC=C3)NC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hu L, et al. Discovery of Novel Alkynylbenzene Scaffold-Based PTPN2-Selective Degrader PD-305 with Exceptional Potency and In Vivo Efficacy. J Med Chem. 2026;69(10):11998-12019. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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CRBN ligand-905

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CRBN ligand-905 Related Classifications

HY-184258 Related Classifications