CRBN ligand-905
CRBN ligand-905 is a naphtholactam-based CRBN E3 ligase ligand used in the design of PTPN2 PROTAC degraders PD-305 (HY-183937).
For research use only. We do not sell to patients.
- CAS No.: 2504233-60-5
- Formula: C16H12N2O3
- Molecular Weight:280.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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Cereblon |
In Vitro
CRBN ligand-905 (compound 21) enables subnanomolar PTPN2 degradation potency (DC50 = 0.25 nM) and over 20-fold selectivity for PTPN2 over PTPN1 in human Jurkat cells when connected to the PTPN2 targeting ligand via an appropriate linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2504233-60-5
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Molecular Weight 280.28
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Formula C16H12N2O3
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SMILES
O=C(C(CC1)N2C3=C4C(C=CC=C4C2=O)=CC=C3)NC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CRBN ligand-905 Related Classifications
HY-184258 Related Classifications
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