PTPN2/1-IN-4
PTPN2/1-IN-4 (Compound WS35) is an orally active, dual-functional inhibitor of PTPN1 and PTPN2 with IC50s of 12.8 and 5.8 nM for PTPN1 and PTPN2, respectively. PTPN2/1-IN-4 modulates the IFNγ-JAK-STAT signaling pathway and significantly augments CD8+ T-cell tumor infiltration. PTPN2/1-IN-4 has potent anticancer activity, robustly inhibiting tumor growth both as a monotherapy and in combination with an anti-PD-1 antibody in B16-OVA syngeneic mouse models.
For research use only. We do not sell to patients.
- CAS No.: 3093350-55-8
- Formula: C19H23FN4O4S
- Molecular Weight:422.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
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STAT1 |
Chemical Information
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CAS No. 3093350-55-8
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Molecular Weight 422.47
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Formula C19H23FN4O4S
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SMILES
FC1=C(C(O)=CC(C2=CN=C(C(C)=C2)NCCC(C)C)=C1)N3CC(NS3(=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PTPN2/1-IN-4 Related Classifications
HY-178716 Related Classifications
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