3093350-55-8
Chemical Structure
PTPN2/1-IN-4
- CAS No.: 3093350-55-8
- Formula:C19H23FN4O4S
- Molecular Weight:422.47
InChIKey: JIWTUVSQAPKQGC-UHFFFAOYSA-N
SMILES: FC1=C(C(O)=CC(C2=CN=C(C(C)=C2)NCCC(C)C)=C1)N3CC(NS3(=O)=O)=O
Biological Activity: PTPN2/1-IN-4 (Compound WS35) is an orally active, dual-functional inhibitor of PTPN1 and PTPN2 with IC50s of 12.8 and 5.8 nM for PTPN1 and PTPN2, respectively. PTPN2/1-IN-4 modulates the IFNγ-JAK-STAT signaling pathway and significantly augments CD8+ T-cell tumor infiltration. PTPN2/1-IN-4 has potent anticancer activity, robustly inhibiting tumor growth both as a monotherapy and in combination with an anti-PD-1 antibody in B16-OVA syngeneic mouse models[1].
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PTPN2/1-IN-4 | PTPN2/1-IN-4 (Compound WS35) is an orally active, dual-functional inhibitor of PTPN1 and PTPN2 with IC50s of 12.8 and 5.8 nM for PTPN1 and PTPN2, respectively. PTPN2/1-IN-4 modulates the IFNγ-JAK-STAT signaling pathway and significantly augments CD8+ T-cell tumor infiltration. PTPN2/1-IN-4 has potent anticancer activity, robustly inhibiting tumor growth both as a monotherapy and in combination with an anti-PD-1 antibody in B16-OVA syngeneic mouse models. | |||||||||||||||||||||
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