PROTAC PTPN2 degrader-2
PROTAC PTPN2 degrader-2 is a potent PTPN2 PROTAC degrader with a DC50 of <50 nM. PROTAC PTPN2 degrader-2 is potential for studying cancer or metabolic diseases, such as colon cancer.
For research use only. We do not sell to patients.
- CAS No.: 2912307-38-9
- Formula: C49H49ClN6O11S2
- Molecular Weight:997.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
DC50: <50 nM (PTPN2)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female C57B1/6 mice (7-12 weeks old; ~21 g) injected with MC-38 cells[1]
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Dosage:10 mg/kg
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Administration:i.v.; weekly (QW) for 3 weeks
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Result:Apparent tumor stasis and shrinkage was observed. Was well tolerated, without obvious adverse health events.
Chemical Information
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CAS No. 2912307-38-9
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Molecular Weight 997.53
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Formula C49H49ClN6O11S2
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SMILES
O=C1C2=C3C(N1[C@@H]4C(NC(CC4)=O)=O)=CC=C(C5CCN(CC5)C(NC6=CC(CS(=O)(N7C(C)(C[C@H](CC7)NC8=CC(C9=C(C(OCC(O)=O)=C(S9)C(O)=O)Cl)=CC=C8)C)=O)=CC=C6)=O)C3=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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