PTPN2-IN-2
PTPN2-IN-2 is a potent and orally active PTPN2 inhibitor (IC50 = 7.05 nM) that enhances the IFN-γ signaling pathway. PTPN2-IN-2 inhibits PTP1B with an IC50 of 9.88 nM. PTPN2-IN-2 inhibits tumor growth, promotes the activation and infiltration of tumor immune cells in a B16-OVA mouse model. PTPN2-IN-2 can be used for the research of melanoma.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 3093350-44-5
- 화학식: C19H22FN5O5S
- 분자량:451.47
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
PTPN2 7.05 nM (IC50) |
PTP1B 9.88 nM (IC50) |
PTPN2-IN-2 (compound K-38) (0-100 µM; 24 h) enhances the IFN-γ/JAK/STAT1 signaling pathway in Jurkat and B16 cells, as evidenced by increased STAT1 phosphorylation upon IFN-γ stimulation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Jurkat and B16 cells
-
Concentration:0; 1; 10; 50; 100 µM
-
Incubation Time:24 h
-
Result:Induced an increase in STAT1 phosphorylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female C57BL/6J mice subcutaneously implanted with B16-OVA cells[1]
-
Dosage:50; 100; 150 mg/kg
-
Administration:p.o.; once daily for 24 days
-
Result:Significantly inhibited the volume, proliferation rate and tumor weight of melanoma in mice.
Significantly enhanced the inhibitory activity of PD-1 on tumor growth.
Had no significant effect on the body weight.
Markly increased CD8+ T and CD45+ leukocyte infiltration in B16-OVA tumors.
Increased IFN-γ levels in tumor tissues.
Upreugalted PD-L1 and p-STAT1 levels.
Chemical Information
-
CAS No. 3093350-44-5
-
분자량 451.47
-
화학식 C19H22FN5O5S
-
SMILES
FC1=C(C(O)=CC(C2=CNC(C(NC3CCCCCC3)=O)=N2)=C1)N4CC(NS4(=O)=O)=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PTPN2-IN-2 Related Classifications
HY-179380 Related Classifications
Powered by Bioz