PTPN2 - protein tyrosine phosphatase non-receptor type 2 Gene

Also Known as PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5771

About PTPN2

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:12,785,478-12,884,237 (from NCBI)

This gene has 21 transcripts (splice variants), 284 orthologues, 35 paralogues and is associated with 4 phenotypes. Ubiquitous expression in appendix (RPKM 7.7), lymph node (RPKM 7.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

PTPN2 Products (5)

mRNA	Protein	Name
NM_001207013.2	NP_001193942.1	tyrosine-protein phosphatase non-receptor type 2 isoform 4
NM_001308287.1	NP_001295216.1	tyrosine-protein phosphatase non-receptor type 2 isoform 5
NM_002828.4	NP_002819.2	tyrosine-protein phosphatase non-receptor type 2 isoform 1
NM_080422.3	NP_536347.1	tyrosine-protein phosphatase non-receptor type 2 isoform 2
NM_080423.3	NP_536348.1	tyrosine-protein phosphatase non-receptor type 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	15592458	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12359225	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11909529	GOA
enables protein tyrosine phosphatase activity	EXP EXP: Inferred from Experiment	12138178	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	12138178	GOA
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	11909529	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	18819921	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	23006999	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15592458	GOA
involved in negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15592458	GOA
involved in negative regulation of interleukin-2-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11909529	GOA
involved in negative regulation of interleukin-4-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	17210636	GOA
involved in negative regulation of interleukin-6-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12359225	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11909529	GOA
NOT involved in negative regulation of type II interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	12138178	GOA
involved in negative regulation of type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12138178	GOA
involved in negative regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	12359225	GOA
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	11909529	GOA
involved in regulation of hepatocyte growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18819921	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	7593185	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	23006999	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7593185	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	15592458	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN2 Protein Structure

Y_phosphatase

0
100
200
300
415 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type 2	T-cell protein tyrosine phosphatase

PTPN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTPN2	P17706	COL5A1	Homo sapiens	P20908	Anti Tag CoIP	33961781
Intra	PTPN2	P17706	COL5A1	Homo sapiens	P20908	Anti Tag CoIP	28514442
Cross	PTPN2	P17706	q2ghu2_ehrcr	Ehrlichia chaffeensis	Q2GHU2	Confocal	19273555
Intra	PTPN2	P17706	GHR	Homo sapiens	P10912	Array	12907755

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76103	TCPTP Protein, Human (sf9, solution)	P17706-1 (N-G&P, M1-N314)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76104	TCPTP Protein, Human (sf9, His-GST)	P17706-1 (M1-N314)	≥ 80%, as determined by reducing SDS-PAGE.

PTPN2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87102	TCPTP Antibody (YA6795)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Oligoarticular Juvenile Idiopathic Arthritis	Oligoarticular Jia Pauciarticular Chronic Arthritis Juvenile Pauciarticular Chronic Arthritis
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis	Juvenile Polyarthritis Without Rheumatoid Factor Juvenile Rheumatoid Factor-Negative Polyarthritis Rheumatoid Factor-Negative Polyarticular Jia Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative
Inflammatory Bowel Disease 20	IBD20
Inflammatory Bowel Disease 1	Inflammatory Bowel Disease 1 IBD1 Crohn Disease-Associated Growth Failure Crohn Disease Regional Enteritis Ulcerative Colitis Crohn Disease-Associated Growth Failure, Susceptibility To Inflammatory Bowel Disease 1, Crohn Disease Bowel Disease, Inflammatory, Type 1
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Diabetes Mellitus	Diabetes
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145923	Osunprotafib	Inhibitor	99.43%	Phase 1

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148691	PROTAC PTPN2 degrader-1	Degrader	/	Unkown
HY-153446	Tegeprotafib	Inhibitor	99.30%	Unkown
HY-162428	PTPN2/1-IN-3	Inhibitor	99.89%	Unkown
HY-149760	PVD-06	Inhibitor	98.30%	Unkown
HY-153638	PTPN2/1-IN-2	Antagonist	99.56%	Unkown
HY-RS11421	PTPN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-145923B	Osunprotafib hydrochloride	Inhibitor	/	Unkown
HY-153938	PROTAC PTPN2 degrader-2		/	Unkown
HY-153938A	PROTAC PTPN2 degrader-2 TFA		/	Unkown
HY-156606	Anticancer agent 142	Inhibitor	/	Unkown
HY-156607	Anticancer agent 143	Inhibitor	/	Unkown
HY-156608	Anticancer agent 144	Inhibitor	/	Unkown
HY-163596	PTPN2-IN-1	Inhibitor	/	Unkown
HY-168691	PTPN2 ligand 1	Ligand	/	Unkown
HY-175618	PTPN2 ligand 2	Ligand	/	Unkown
HY-175619	PTPN2 ligand-Linker Conjugate 1	Ligand	/	Unkown
HY-178716	PTPN2/1-IN-4		/	Unkown
HY-179380	PTPN2-IN-2		/	Unkown
HY-181255	PTPN2-IN-3	Inhibitor	/	Unkown
HY-183937A	PD-305		/	Unkown
HY-184259	PTPN2 ligand 4	Degrader	/	Unkown
HY-W585105	PTPN2 ligand 3	Ligand	/	Unkown
HY-W733139	3-[2-Oxo-6-(4-Pip)-Bz[cd]indol-1-yl]-Pip-2,6-dione		/	Unkown
HY-RS16588	Ptpn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23023	Ptpn2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PTPN2	VGNC	VGNC:33534
Mus musculus	PTPN2	MGD	MGI:97806
Felis catus	PTPN2	VGNC	VGNC:80468
Rattus norvegicus	PTPN2	RGD	RGD:620710
Canis familiaris	PTPN2	VGNC	VGNC:45172
Macaca mulatta	PTPN2	VGNC	VGNC:104236
Others	PTPN2	NCBI