2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies
  5. TCPTP Antibody (YA6795)

TCPTP Antibody (YA6795) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TCPTP.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量 価格（税別） 在庫状況
20 μL $167 見積もりとリードタイムを求めるのご確認
50 μL $252 見積もりとリードタイムを求めるのご確認
100 μL $408 見積もりとリードタイムを求めるのご確認

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

TCPTP Antibody (YA6795) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TCPTP.
Host

Rabbit
Clonality

Recombinant,Monoclonal
分子量

Predicted band size: 48 kDa
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

Recombinant protein within human TCPTP aa 1-100/415.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:2000
FC
FC: Flow Cytometry
1:500-1:1000
純度 affinity purified. Conjugation Non-conjugated
Modification Unmodified Isotype IgG
Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA
Subcellular Localization：Endoplasmic reticulum,Endoplasmic reticulum-Golgi intermediate compartment,Nucleus,Cytoplasm,Cell membrane
Expression：
Tissue_Specificity: Ubiquitously expressed. Isoform 2 is probably the major isoform. Isoform 1 is expressed in T-cells and in placenta
Induction: Up-regulated by IL4/interleukin-4 (at protein level)
Isoforms & Post-Translational Modification：P17706 has four isomers: P17706-1: 48473 Da (predicted); P17706-2: 45168 Da (predicted); P17706-3: 40990 Da (predicted); P17706-4: 48017 Da (predicted).
Specifically phosphorylated in a cell cycle-dependent manner by cyclin-dependent kinases CDK1 and CDK2
Subunit：Interacts with RMDN3
Synonyms
Protein tyrosine phosphatase non receptor type 2 antibody; PTN2 antibody; PTN2_HUMAN antibody; PTPN 2 antibody; Ptpn2 antibody; PTPT antibody; T cell protein tyrosine phosphatase antibody; T-cell protein-tyrosine phosphatase antibody; TC PTP antibody; TCELLPTP antibody; Protein tyrosine phosphatase non receptor type 2 antibody; PTN2 antibody; PTN2_HUMAN antibody; PTPN 2 antibody; Ptpn2 antibody; PTPT antibody; T cell protein tyrosine phosphatase antibody; T-cell protein-tyrosine phosphatase antibody; TC PTP antibody; TCELLPTP antibody; TCPTP antibody; Tyrosine protein phosphatase non receptor type 2 antibody; Tyrosine-protein phosphatase non-receptor type 2 antibody;
ドキュメンテーション
User Guide for Antibodies (1077 KB)

TCPTP Antibody (YA6795) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
TCPTP Antibody (YA6795)
製品番号:
HY-P87102
数量:
MCE 日本正規代理店:

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

国或いは地域 *

メールアドレス *

     

電話番号 *

 

組纖名 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.