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Cat. No.: HY-175619

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PTPN2 ligand-Linker Conjugate 1

PTPN2 ligand-Linker Conjugate 1 is a conjugate of the PTPN2 target protein ligand and linker, which can be used for the synthesis of PROTACs, such as PROTAC PTPN2 degrader-2 (HY-153938).

For research use only. We do not sell to patients.

Formula: C₂₈H₃₀ClN₃O₉S₂
Molecular Weight:652.14

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PTPN2 ligand-Linker Conjugate 1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PTPN2 ligand-Linker Conjugate 1 is a conjugate of the PTPN2 target protein ligand and linker, which can be used for the synthesis of PROTACs, such as PROTAC PTPN2 degrader-2 (HY-153938)^[1].

Chemical Information

Molecular Weight 652.14
Formula C₂₈H₃₀ClN₃O₉S₂
SMILES

OC(NC1=CC(CS(=O)(N2C(C)(C[C@H](CC2)NC3=CC(C4=C(C(OCC(O)=O)=C(S4)C(O)=O)Cl)=CC=C3)C)=O)=CC=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jingyu Zhang, et al. Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia, European Journal of Medicinal Chemistry, Volume 262, 2023, 115872. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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