ANGPTL8/Angiopoietin-like 8 Protein, Mouse (H40A, Q44A, Q47A, His)

ANGPTL8, a blood lipid regulator, controls serum triglyceride levels and orchestrates metabolic transitions during fasting and refeeding. Its role involves directing fatty acid storage in adipose tissue during the fed state. Though its precise mechanism is not fully understood, ANGPTL8 has been suggested to promote ANGPTL3 cleavage, interacting with ANGPTL3 for regulatory functions in lipid metabolism. ANGPTL8/Angiopoietin-like 8 Protein, Mouse (H40A, Q44A, Q47A, His) is the recombinant mouse-derived ANGPTL8/Angiopoietin-like 8 protein, expressed by E. coli , with C-6*His labeled tag and H40A, Q44A, Q47A inactivating mutations^[1].

ANGPTL8, known as a blood lipid regulator, plays a pivotal role in controlling serum triglyceride levels. This hormone is implicated in orchestrating the metabolic transition between fasting and refeeding, facilitating the directed storage of fatty acids in adipose tissue during the fed state. While its precise mechanism is not fully elucidated, ANGPTL8 has been suggested to promote ANGPTL3 cleavage according to one report, although another study contradicts this claim by stating that ANGPTL8 is not required for ANGPTL3 cleavage. Notably, ANGPTL8 engages in interactions with ANGPTL3, further contributing to its regulatory functions in lipid metabolism.

Mouse

E. coli

C-6*His

Q8R1L8 (V16-A198, H40A, Q44A, Q47A)

624219  [NCBI]

Full Length of Mature Protein

VRPAPVAPLGGPEPAQYEELTLLFAGALALGAALNGVYRATEARLTEAGHSLGLYDRALEFLGTEVRQGQDATQELRTSLSEIQVEEDALHLRAEATARSLGEVARAQQALRDTVRRLQVQLRGAWLGQAHQEFETLKARADKQSHLLWALTGHVQRQQREMAEQQQWLRQIQQRLHTAALPA

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. /biology-dictionary/kasumi-1-cell.html  [Content Brief]

  [2]. Jorge F. Haller, et al. ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance. J Lipid Res. 2017 Jun; 58(6): 1166-1173.  [Content Brief]