2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. Papain

Papain is a cysteine protease of the peptidase C1 family. Papain enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain can induce pulmonary emphysema. Papain can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema.

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Papain

Papain Chemical Structure

CAS No. : 9001-73-4

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Based on 15 publication(s) in Google Scholar

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Papain Related Antibodies

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Description

Papain is a cysteine protease of the peptidase C1 family. Papain enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain can induce pulmonary emphysema. Papain can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema[1][2].

In Vitro

Papain (5 U/mL; 15 min) pretreatment of O Rh-positive red cells enhances anti-D-mediated agglutination, while it slightly reduces anti-A-mediated agglutination of A Rh-negative red cells[2].
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive red cells increases their sensitivity to lymphocyte-mediated lysis in anti-D-mediated ADCC assays at low antibody concentrations and a 15:1 effector-to-target ratio[2].
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive target red cells enables significant PBMC-mediated lysis in anti-D-mediated ADCC assays at a 1:3:3 effector-to-target-to-competitor ratio[2].
Papain (5 U/mL; 15 min) pretreatment of A Rh-negative target red cells enables significant PBMC-mediated lysis in anti-A-mediated ADCC assays at a 1:3:3 effector-to-target-to-competitor ratio[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Papain Related Antibodies
In Vivo

Papain (10 IU; intratracheal instillatio; at day 0 and 7) induces pulmonary emphysema in female BALB/c mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, 20-25 g)[1]
Dosage: 10 IU
Administration: Intratracheal instillatio; days 0 and 7
Result: Increased viscoelastic/inhomogeneous pressure, static elastance, and viscoelastic component of elastance.
Increased polymorphonuclear (PMN) cell count, mean alveolar diameter, functional residual capacity (FRC) and decreased elastic fiber area.
Increased KC levels, MIP-2 levels, and IFN-γ levels.
Left TNF-α, IL-1β, and IL-6 levels unchanged relative to saline controls.
Clinical Trial
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Papain]
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (Need ultrasonic)

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Purity & Documentation

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Papain Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Papain9001-73-4Cathepsindual oxidase 1dual oxidase 2polymorphonuclear cellred cell membranekeratinocyte derived chemokineinterferon-gammahydrogen peroxidemacrophage inflammatory protein-2BALB/c micepulmonary elastic fibersInhibitorinhibitorinhibit

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