Papain (1.5-10 units/mg)
Based on 1 Customer Validation
Papain (1.5-10 units/mg) is a cysteine protease of the peptidase C1 family. Papain (1.5-10 units/mg) enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain (1.5-10 units/mg) can induce pulmonary emphysema. Papain (1.5-10 units/mg) can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema.
For research use only. We do not sell to patients.
- CAS No.: 9001-73-4
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-P1645
Papain
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HY-P1645B
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HY-129047
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Peroxidase, Horseradish
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HY-129047A
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Myeloperoxidase, human white blood cells
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Pepsin
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HY-P2902
Glucose oxidase
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HY-129047E
Trypsin, porcine pancreas (Cell culture grade)
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HY-129047B
Recombinant Trypsin Solution
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HY-125859B
Lactoperoxidase, bovine milk
All Cathepsin Isoforms
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Biological Activity
Papain (1.5-10 units/mg) (5 U/mL; 15 min) pretreatment of O Rh-positive red cells enhances anti-D-mediated agglutination, while it slightly reduces anti-A-mediated agglutination of A Rh-negative red cells[2].
Papain (1.5-10 units/mg) (5 U/mL; 15 min) pretreatment of O Rh-positive red cells increases their sensitivity to lymphocyte-mediated lysis in anti-D-mediated ADCC assays at low antibody concentrations and a 15:1 effector-to-target ratio[2].
Papain (1.5-10 units/mg) (5 U/mL; 15 min) pretreatment of O Rh-positive target red cells enables significant PBMC-mediated lysis in anti-D-mediated ADCC assays at a 1:3:3 effector-to-target-to-competitor ratio[2].
Papain (1.5-10 units/mg) (5 U/mL; 15 min) pretreatment of A Rh-negative target red cells enables significant PBMC-mediated lysis in anti-A-mediated ADCC assays at a 1:3:3 effector-to-target-to-competitor ratio[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 20-25 g)[1]
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Dosage:10 IU
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Administration:Intratracheal instillatio; days 0 and 7
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Result:Increased viscoelastic/inhomogeneous pressure, static elastance, and viscoelastic component of elastance.
Increased polymorphonuclear (PMN) cell count, mean alveolar diameter, functional residual capacity (FRC) and decreased elastic fiber area.
Increased KC levels, MIP-2 levels, and IFN-γ levels.
Left TNF-α, IL-1β, and IL-6 levels unchanged relative to saline controls.
Chemical Information
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CAS No. 9001-73-4
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Appearance Solid
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SMILES
[Papain (1.5-10 units/mg)]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Machado MN, et al. Bone Marrow-Derived Mononuclear Cell Therapy in Papain-Induced Experimental Pulmonary Emphysema. Front Physiol. 2018 Feb 20;9:121. [Content Brief]
[2]. B M Kumpel, et al. Comparison of lysis of bromelain and papain treated red cells in ADCC assays.Immunol Lett. 1992 Feb 15;31(3):237-40. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Papain (1.5-10 units/mg) Related Classifications
HY-P1645A Related Classifications
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