21438-66-4
Chemical Structure
Gly-Phe-β-naphthylamide
- CAS No.: 21438-66-4
- Formula:C21H21N3O2
- Molecular Weight:347.42
IUPAC Name: (S)-2-(2-aminoacetamido)-N-(naphthalen-2-yl)-3-phenylpropanamide
InChIKey: YABDXPBHLDPMOA-IBGZPJMESA-N
SMILES: O=C([C@@H](NC(CN)=O)CC1=CC=CC=C1)NC2=CC3=C(C=CC=C3)C=C2
Biological Activity: Gly-Phe-β-naphthylamide is a substrate of Cathepsin C (HY-P2922) and belongs to the lysosomal agonist. Gly-Phe-β-naphthylamide can freely pass through the cell membrane and organelle membrane. Gly-Phe-β-naphthylamide will be specifically hydrolyzed by Cathepsin C, ultimately leading to a permeability lysis when it enters the acidic compartment. Gly-Phe-β-naphthylamide can be used to study lysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Gly-Phe-β-naphthylamide | 99.97% | Gly-Phe-β-naphthylamide is a substrate of Cathepsin C (HY-P2922) and belongs to the lysosomal agonist. Gly-Phe-β-naphthylamide can freely pass through the cell membrane and organelle membrane. Gly-Phe-β-naphthylamide will be specifically hydrolyzed by Cathepsin C, ultimately leading to a permeability lysis when it enters the acidic compartment. Gly-Phe-β-naphthylamide can be used to study lysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C. | ||||||||||||||||||||
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Similarity Score 0.74
HY-137116Ser-Tyr β-naphthylamide -
Similarity Score 0.74
HY-P4303H-Gly-Trp-βNA -
Similarity Score 0.71
HY-101444MC-207110 -
Similarity Score 0.70
HY-101444APAβN dihydrochloride -
Similarity Score 0.69
HY-W142009L-Tyrosine β-naphthylamide -
Similarity Score 0.68
HY-P4425Gly-Phe-AMC -
Similarity Score 0.67
HY-P4528Ala-Phe-Pro-βNA -
Similarity Score 0.66
HY-114318Bz-DL-Arg-βNA hydrochloride -
Similarity Score 0.65
HY-184407D-AAP1 -
Explore the MedChemAI to find more analogs
References
- [1]. Baumgartner HK, et, al. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G296-307. [Content Brief]
- [2]. Serrano D, et al. GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes. Front Immunol. 2017 Feb 7;8:94. [Content Brief]
- [3]. Two-pore channel 1 and Ca2+ release-activated Ca2+ channels contribute to the acrosomal pH-dependent intracellular Ca2+ increase in mouse sperm [Content Brief]
