1. Anti-infection
  2. Bacterial
  3. PAβN dihydrochloride

PAβN dihydrochloride (Synonyms: MC-207,110 dihydrochloride; Phe-Arg-β-naphthylamide dihydrochloride)

Cat. No.: HY-101444A Purity: 99.89%
Handling Instructions

PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.

For research use only. We do not sell to patients.

PAβN dihydrochloride Chemical Structure

PAβN dihydrochloride Chemical Structure

CAS No. : 100929-99-5

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Customer Review

Based on 2 publication(s) in Google Scholar

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Publications Citing Use of MCE PAβN dihydrochloride

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Description

PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.

In Vitro

PAβN increases the susceptibilities of the three pump-overexpressing mutants of P. aeruginosa to levofloxacin 64-fold. PAβN also potentiates the activity of levofloxacin against strain PAM2391 containing plasmid pAGH97 with the mexXY genes and against wild-type strain PAM1020. PAβN has an effect on susceptibilities to other antibiotics that are substrates of efflux pumps. PAβN increases levels of accumulation of efflux pump substrates inside the cell. It enhances the activity of levofloxacin against clinical isolates of P. aeruginosa[1]. PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold. Moreover, PAβN restores ciprofloxacin susceptibility in five of the ciprofloxacin-resistant isolates. In addition, clear effects of NMP on the ciprofloxacin MICs are seen for 20 of these ciprofloxacin-resistant isolates[2]. PAβN permeabilizes bacterial membranes in a concentration-dependent manner at levels below those typically used in combination studies, and this additional mode of action should be considered when using PAβN as a control for efflux studies[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

519.47

Formula

C₂₅H₃₂Cl₂N₆O₂

CAS No.

100929-99-5

SMILES

O=C([[email protected]](CCCNC(N)=N)NC([[email protected]](CC1=CC=CC=C1)N)=O)NC2=CC(C=CC=C3)=C3C=C2.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (160.41 mM; Need ultrasonic)

H2O : 14.29 mg/mL (27.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9250 mL 9.6252 mL 19.2504 mL
5 mM 0.3850 mL 1.9250 mL 3.8501 mL
10 mM 0.1925 mL 0.9625 mL 1.9250 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.00 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.89%

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Keywords:

PAβNMC-207,110Phe-Arg-β-naphthylamideBacterialInhibitorinhibitorinhibit

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Product Name:
PAβN dihydrochloride
Cat. No.:
HY-101444A
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