MC-207110

Cat. No.: HY-101444: Data Sheet Handling Instructions
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MC-207110 is a broad-spectrum efflux pump inhibitor. MC-207110 is active against all three known Mex efflux pumps from P. aeruginosa and their close Escherichia coli efflux pump homolog (AcrAB-TolC). MC-207110 can decrease the intrinsic resistance of P. aeruginosa to fluoroquinolones. MC-207110 can be used for the research of infection .

For research use only. We do not sell to patients.

CAS No. : 115871-02-8

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Other In-stock Forms of MC-207110:

PAβN dihydrochloride

Other Forms of MC-207110:

PAβN dihydrochloride In-stock

11 Publications Citing Use of MCE MC-207110

Bio/Physico-chemical Assay

Microbiological Assay

: MC-207110 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Jul 22;44(7):115987. [Abstract]; Effect of efflux pump inhibitors (CCCP (10 mg/L), NMP (25 mg/L ), and PAβN dihydrochloride (25 mg/L)) on the susceptibility of evolved strains to tigecycline (n = 2). PAβN dihydrochloride lowered the MIC values and reversed the tigecycline-resistance phenotypes, suggesting a role for increased efflux pump activity in tigecycline resistance.

: MC-207110 purchased from MedChemExpress. Usage Cited in: Front Microbiol. 2024 Sep 24:15:1417237. [Abstract]; The results of tigecycline combined with PAβN dihydrochloride (20 mg/L) demonstrated that 20 TNSKP strains exhibited a fold decrease ≥ 4 in MIC after co-incubation with PAβN, but 2 strains of TSKP did not show any change in MIC under the effect of efflux pump inhibitor.

: MC-207110 purchased from MedChemExpress. Usage Cited in: Microb Pathog. 2023 Dec:185:106397. [Abstract]; PAβN dihydrochloride (50 μg/mL; 50 μL; 24 h)。 Results of screening test strains.

: MC-207110 purchased from MedChemExpress. Usage Cited in: Front Cell Infect Microbiol. 2021 Mar 25;11:660431. [Abstract]; BBH uptake with pump inhibitors CCCP, PAβN dihydrochloride (50 µM; 60 min), and reserpine in ATCC 19606 strain, MDR-B and △adeB MDR-B strains, and MDR-TJ and △adeB MDR-TJ strains. Red arrows indicate the pump inhibitors (50 µM) were added at 60 min. Grey letters indicate the inhibitors were added to the adeB knockout strains.

: MC-207110 purchased from MedChemExpress. Usage Cited in: Microb Drug Resist. 2020 Jun;26(6):550-560. [Abstract]; PAβN dihydrochloride (50-200 μg/mL) and NMP inhibited OqxB activity in a concentration-dependent manner, suggesting that an efflux pump (OqxAB) is indeed responsible for the decreased susceptibility of the overexpression system.

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	CC₅₀	>100 μM Compound: PAbetaN	Cytotoxicity against HEK293 cells incubated for 24 hrs by MTT assay Cytotoxicity against HEK293 cells incubated for 24 hrs by MTT assay	[PMID: 37672933]
LX-2	CC₅₀	>100 μM Compound: PAbetaN	Cytotoxicity against human LX2 cells incubated for 24 hrs by MTT assay Cytotoxicity against human LX2 cells incubated for 24 hrs by MTT assay	[PMID: 37672933]

Molecular Weight

446.54

Formula

C₂₅H₃₀N₆O₂

CAS No.

115871-02-8

SMILES

O=C([C@H](CCCNC(N)=N)NC([C@H](CC1=CC=CC=C1)N)=O)NC2=CC(C=CC=C3)=C3C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lomovskaya O, et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother. 2001 Jan;45(1):105-16. [Content Brief]

MC-207110 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-207110115871-02-8MC207110MC 207110Bacterialefflux pumpMexP. aeruginosaEscherichia coliAcrAB-TolCfluoroquinolonesinfectionInhibitorinhibitorinhibit

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