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Cat. No.: HY-101444

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MC-207110

Name: MC-207110
Brand: MedChemExpress
SKU: HY-101444
Availability: PreOrder

12 Cited Publications

Customer Review

Based on 12 publication(s) in Google Scholar

MC-207110 is a broad-spectrum efflux pump inhibitor. MC-207110 is active against all three known Mex efflux pumps from P. aeruginosa and their close Escherichia coli efflux pump homolog (AcrAB-TolC). MC-207110 can decrease the intrinsic resistance of P. aeruginosa to fluoroquinolones. MC-207110 can be used for the research of infection .

For research use only. We do not sell to patients.

CAS No.: 115871-02-8
Formula: C₂₅H₃₀N₆O₂
Molecular Weight:446.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

MC-207110 Chemical Structure

CAS No.: 115871-02-8

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Top Publications Citing

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Publications (12)
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	CC₅₀	>100 μM Compound: PAbetaN	Cytotoxicity against HEK293 cells incubated for 24 hrs by MTT assay Cytotoxicity against HEK293 cells incubated for 24 hrs by MTT assay	[PMID: 37672933]
LX-2	CC₅₀	>100 μM Compound: PAbetaN	Cytotoxicity against human LX2 cells incubated for 24 hrs by MTT assay Cytotoxicity against human LX2 cells incubated for 24 hrs by MTT assay	[PMID: 37672933]

Chemical Information

CAS No. 115871-02-8
Molecular Weight 446.54
Formula C₂₅H₃₀N₆O₂
SMILES

O=C([C@H](CCCNC(N)=N)NC([C@H](CC1=CC=CC=C1)N)=O)NC2=CC(C=CC=C3)=C3C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (12)

All Bio/Physico-chemical AssayMicrobiological Assay

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Journal Impact Factor

Cell Rep

Lon dysfunction-mediated collateral sensitivity drives effective antibiotic combination therapies against tigecycline-resistant pathogens. [Abstract]

2025 Jul 22;44(7):115987. PMID: 40650911

MC-207110 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Jul 22;44(7):115987. [Abstract]

Effect of efflux pump inhibitors (CCCP (10 mg/L), NMP (25 mg/L ), and PAβN dihydrochloride (25 mg/L)) on the susceptibility of evolved strains to tigecycline (n = 2). PAβN dihydrochloride lowered the MIC values and reversed the tigecycline-resistance phenotypes, suggesting a role for increased efflux pump activity in tigecycline resistance.
Front Microbiol

Comparison of antimicrobial activities and resistance mechanisms of eravacycline and tigecycline against clinical Acinetobacter baumannii isolates in China. [Abstract]

2024 Sep 24:15:1417237. PMID: 39380684

MC-207110 purchased from MedChemExpress. Usage Cited in: Front Microbiol. 2024 Sep 24:15:1417237. [Abstract]

The results of tigecycline combined with PAβN dihydrochloride (20 mg/L) demonstrated that 20 TNSKP strains exhibited a fold decrease ≥ 4 in MIC after co-incubation with PAβN, but 2 strains of TSKP did not show any change in MIC under the effect of efflux pump inhibitor.
Front Cell Infect Microbiol

A Potential Combination Therapy of Berberine Hydrochloride With Antibiotics Against Multidrug-Resistant Acinetobacter baumannii. [Abstract]

2021 Mar 25:11:660431. PMID: 33842399

MC-207110 purchased from MedChemExpress. Usage Cited in: Front Cell Infect Microbiol. 2021 Mar 25:11:660431. [Abstract]

BBH uptake with pump inhibitors CCCP, PAβN dihydrochloride (50 µM; 60 min), and reserpine in ATCC 19606 strain, MDR-B and △adeB MDR-B strains, and MDR-TJ and △adeB MDR-TJ strains. Red arrows indicate the pump inhibitors (50 µM) were added at 60 min. Grey letters indicate the inhibitors were added to the adeB knockout strains.
World J Microbiol Biotechnol

AcrAB-TolC efflux pump overexpression and tet(A) gene mutation increase tigecycline resistance in Klebsiella pneumoniae. [Abstract]

2024 Jun 6;40(8):233. PMID: 38842631
Microbiol Spectr

OmpK36 deficiency and inducible AmpC β-lactamase synergistically drive imipenem resistance in Klebsiella aerogenes. [Abstract]

2026 Jul 7;14(7):e0410825. PMID: 42212662
Microbiol Spectr

IITR00803: a benzoxazole-nitrothiophene small molecule with broad-spectrum antibacterial potential. [Abstract]

2025 Sep 2;13(9):e0114425. PMID: 40792514
J Antimicrob Chemother

Identification of a novel plasmid-mediated tigecycline resistance-related gene, tet(Y), in Acinetobacter baumannii. [Abstract]

2021 Dec 24;77(1):58-68. PMID: 34634801
mSphere

RND Pump-Mediated Efflux of Amotosalen, a Compound Used in Pathogen Inactivation Technology to Enhance Safety of Blood Transfusion Products, May Compromise Its Gram-Negative Anti-Bacterial Activity. [Abstract]

2023 Apr 20;8(2):e0067322. PMID: 36853056
Microb Pathog

Effect of piperine on the inhibitory potential of MexAB-OprM efflux pump and imipenem resistance in carbapenem-resistant Pseudomonas aeruginosa. [Abstract]

2023 Dec:185:106397. PMID: 37852553

MC-207110 purchased from MedChemExpress. Usage Cited in: Microb Pathog. 2023 Dec:185:106397. [Abstract]

PAβN dihydrochloride (50 μg/mL; 50 μL; 24 h)。 Results of screening test strains.
Microb Drug Resist

Site-Directed Mutagenesis Reveals Crucial Residues in Escherichia coli Resistance-Nodulation-Division Efflux Pump OqxB. [Abstract]

2020 Jun;26(6):550-560. PMID: 31834851

MC-207110 purchased from MedChemExpress. Usage Cited in: Microb Drug Resist. 2020 Jun;26(6):550-560. [Abstract]

PAβN dihydrochloride (50-200 μg/mL) and NMP inhibited OqxB activity in a concentration-dependent manner, suggesting that an efflux pump (OqxAB) is indeed responsible for the decreased susceptibility of the overexpression system.
Al-Rafidain Journal of Medical Sciences

2025 Feb 11.
bioRxiv

2020 Apr.

Protocols

All Signal Pathway Related

Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lomovskaya O, et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother. 2001 Jan;45(1):105-16. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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1/16
1/16

MC-207110 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Jul 22;44(7):115987. [Abstract]

Customer Validation
Effect of efflux pump inhibitors (CCCP (10 mg/L), NMP (25 mg/L ), and PAβN dihydrochloride (25 mg/L)) on the susceptibility of evolved strains to tigecycline (n = 2). PAβN dihydrochloride lowered the MIC values and reversed the tigecycline-resistance phenotypes, suggesting a role for increased efflux pump activity in tigecycline resistance.
1/16

MC-207110 purchased from MedChemExpress. Usage Cited in: Front Microbiol. 2024 Sep 24:15:1417237. [Abstract]

Customer Validation
The results of tigecycline combined with PAβN dihydrochloride (20 mg/L) demonstrated that 20 TNSKP strains exhibited a fold decrease ≥ 4 in MIC after co-incubation with PAβN, but 2 strains of TSKP did not show any change in MIC under the effect of efflux pump inhibitor.
1/16

MC-207110 purchased from MedChemExpress. Usage Cited in: Microb Pathog. 2023 Dec:185:106397. [Abstract]

Customer Validation
PAβN dihydrochloride (50 μg/mL; 50 μL; 24 h)。 Results of screening test strains.
1/16

MC-207110 purchased from MedChemExpress. Usage Cited in: Front Cell Infect Microbiol. 2021 Mar 25:11:660431. [Abstract]

Customer Validation
BBH uptake with pump inhibitors CCCP, PAβN dihydrochloride (50 µM; 60 min), and reserpine in ATCC 19606 strain, MDR-B and △adeB MDR-B strains, and MDR-TJ and △adeB MDR-TJ strains. Red arrows indicate the pump inhibitors (50 µM) were added at 60 min. Grey letters indicate the inhibitors were added to the adeB knockout strains.
1/16

MC-207110 purchased from MedChemExpress. Usage Cited in: Microb Drug Resist. 2020 Jun;26(6):550-560. [Abstract]

Customer Validation
PAβN dihydrochloride (50-200 μg/mL) and NMP inhibited OqxB activity in a concentration-dependent manner, suggesting that an efflux pump (OqxAB) is indeed responsible for the decreased susceptibility of the overexpression system.

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MC-207110

Publications Citing Use of MedChemExpress (MCE) MC-207110