2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cathepsin
  5. Cathepsin Substrate

Cathepsin Substrate

Cathepsin Isoform Comparison

Cathepsin Substrates (19):

Cat. No. Product Name Effect Purity
  • HY-134434
    Z-Arg-Arg-AMC hydrochloride
    		Substrate 99.83%
    Z-Arg-Arg-AMC hydrochloride is a highly selective fluorescent Cathepsin B substrate. Z-Arg-Arg-AMC hydrochloride can be hydrolyzed by Cathepsin B to produce a fluorescent product for enzyme activity detection.
  • HY-112111
    Poly-L-Glutamic acid (MW 700000)
    		Substrate 98.36%
    Poly-L-Glutamic acid (MW 700000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-Glutamic acid is an ideal tumor-targeting polymer carrier. Poly-L-Glutamic acid can be hydrolyzed by cathepsin B during metabolic decomposition.
  • HY-142021
    Z-Leu-Arg-AMC
    		Substrate 99.24%
    Z-Leu-Arg-AMC is a fluorogenic peptide substrate for cysteine proteases (e.g., Cathepsin) (Ex=350 nm，Em=460 nm). Z-Leu-Arg-AMC is preferentially cleaved by Cathepsin K and S under weakly acidic conditions, while its hydrolysis relies on residual Cathepsin S activity at neutral pH. Z-Leu-Arg-AMC serves as a substrate for recombinant Sphenophorus levis Cathepsin L, falcipain-2, falcipain-3, berghepain-2, knowlepain-2, vivapain-2, as well as falcipain-2 chimeras and constructs. It enables quantitative detection of cysteine protease activity in human inflammatory bronchoalveolar lavage fluid via fluorescence generation. Z-Leu-Arg-AMC can be used in research related to pulmonary inflammatory diseases and malaria.
  • HY-P1759B
    N-CBZ-Phe-Arg-AMC TFA
    		Substrate 99.79%
    N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes.
  • HY-P1759A
    N-CBZ-Phe-Arg-AMC hydrochloride
    		Substrate 99.40%
    N-CBZ-Phe-Arg-AMC (Z-FR-AMC) hydrochloride is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes.
  • HY-P1759
    N-CBZ-Phe-Arg-AMC
    		Substrate 99.88%
    N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes.
  • HY-164278
    diABZI-V/C-Mal
    		Substrate 99.28%
    diABZI-V/C-Mal is a STING agonist (with a STING EC50 of 314 nM in TH1 dual reporter cells) and a Cathepsin B substrate. diABZI-V/C-Mal activates STING, thereby triggering the IRF3 signaling pathway. diABZI-V/C-Mal is cleaved by Cathepsin B to regenerate diABZI-NH2.
  • HY-W596474D
    Poly-L-glutamic acid sodium salt (MW 30000)
    		Substrate
    Poly-L-glutamic acid sodium salt (MW 30000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
  • HY-W596474C
    Poly-L-glutamic acid sodium salt (MW 15000)
    		Substrate
    Poly-L-glutamic acid sodium salt (MW 15000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
  • HY-W596474B
    Poly-L-glutamic acid sodium salt (MW 7500)
    		Substrate
    Poly-L-glutamic acid sodium salt (MW 7500) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
  • HY-W596474H
    Poly-L-glutamic acid sodium salt (MW 60000)
    		Substrate
    Poly-L-glutamic acid sodium salt (MW 60000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
  • HY-P4787A
    Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 acetate
    		Substrate 99.44%
    Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 acetate is a Cathepsin D substrate, that can be used for cathepsin D FRET assay.
  • HY-118959A
    S2160 hydrochloride
    		Substrate
    S2160 hydrochloride is a substrate of Cathepsin B that can be utilized in the calorimetric assay for the measurement of cathepsin B.
  • HY-W596474I
    Poly-L-glutamic acid sodium salt (MW 120000)
    		Substrate
    Poly-L-glutamic acid sodium salt (MW 120000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
  • HY-P11326
    Ac-FR-AFC TFA
    		Substrate 99.51%
    Ac-FR-AFC TFA is a fluorometric substrate for cathepsin L. Ac-FR-AFC TFA can be used for the research of glioblastoma.
  • HY-P11325
    Ac-RR-AFC TFA
    		Substrate 99.56%
    Ac-RR-AFC TFA is a Cathepsin B fluorogenic substrate (Ex=400 nm, Em=505 nm). Cathepsin B activity in cells lysates is determined by measuring cleavage of Ac-RR-AFC TFA and its cleavage occurs at the RR-AFC amide bond. Ac-RR-AFC TFA can be used for activity assays and mechanistic studies on cathepsin B.
  • HY-112111A
    Poly-L-Glutamic acid (MW 100000)
    		Substrate
    Poly-L-Glutamic acid (MW 100000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-Glutamic acid is an ideal tumor-targeting polymer carrier. Poly-L-Glutamic acid can be hydrolyzed by cathepsin B during metabolic decomposition.
  • HY-W596474A
    Poly-L-glutamic acid sodium salt (MW 3000)
    		Substrate
    Poly-L-glutamic acid sodium salt (MW 3000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
  • HY-W596474E
    Poly-L-glutamic acid sodium salt (MW 45000)
    		Substrate
    Poly-L-glutamic acid sodium salt (MW 45000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.