Val-Cit-PABC-DOX
Based on 1 Customer Validation
Val-Cit-PABC-DOX is an ε-poly-L-lysine-based drug conjugate, serving as a drug-linker conjugate for ADC. It is formed by conjugating Doxorubicin (HY-15142), an inhibitor of DNA topoisomerase I and topoisomerase II, with Val-Cit-PABC. Val-Cit-PABC-DOX relies on the self-cleavable PABC spacer to enable Cathepsin B-mediated linker cleavage and release of free Doxorubicin (HY-15142A). Val-Cit-PABC-DOX can be used in cancer-related research.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 1022094-34-3
- 화학식: C46H56N6O16
- 분자량:948.97
-
보관:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
MoreAll Topoisomerase Isoforms
MoreAll Cathepsin Isoforms
More
Biological Activity
|
Traditional Cytotoxic Agents |
Val-Cit-PABC-DOX exhibits good stability in human plasma and is cleaved by cathepsin B to release free DOX[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1022094-34-3
-
Appearance Solid
-
분자량 948.97
-
화학식 C46H56N6O16
-
Color Orange to red
-
SMILES
OC1=C(C(C2=CC=CC(OC)=C2C3=O)=O)C3=C(O)C4=C1C[C@](C(CO)=O)(O)C[C@@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC(OCC6=CC=C(C=C6)NC([C@H](CCCNC(N)=O)NC([C@@H](N)C(C)C)=O)=O)=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
순도&문서
-
Data Sheet (280 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Val-Cit-PABC-DOX Related Classifications
HY-160774 Related Classifications
Powered by Bioz