Poly-L-Glutamic acid (MW 700000)
Based on 1 Customer Validation
Poly-L-Glutamic acid (MW 700000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-Glutamic acid is an ideal tumor-targeting polymer carrier. Poly-L-Glutamic acid can be hydrolyzed by cathepsin B during metabolic decomposition.
For research use only. We do not sell to patients.
- Purity: 98.36%
- CAS No.: 25513-46-6
- Formula: (C5H9NO4)x
- Molecular Weight:700000 (Average)
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Storage:
RT, protect from light.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Poly-L-Glutamic acid acts as a covalent carrier for Paclitaxel (TXL) (HY-B0015) to form PG-TXL (CT-2103)[1].
Poly-L-Glutamic acid is used to construct targeted hybrid peptosomes co-loaded with Doxorubicin (HY-15142A) and USPIONs as a theranostic platform for metastatic breast cancer[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 25513-46-6
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Appearance Solid
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Molecular Weight 700000 (Average)
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Formula (C5H9NO4)x
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Color White to off-white
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SMILES
OC(CC[C@H](N)C(O)=O)=O.[x]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
RT, protect from light
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
H2O : 100 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Singer JW, et al. Poly-(L)-glutamic acid-paclitaxel (CT-2103) [XYOTAX], a biodegradable polymeric drug conjugate: characterization, preclinical pharmacology, and preliminary clinical data. Adv Exp Med Biol. 2003;519:81-99. [Content Brief]
[2]. Li C. Poly(L-glutamic acid)--anticancer drug conjugates. Adv Drug Deliv Rev. 2002 Sep 13;54(5):695-713. [Content Brief]
[3]. Hasannia M, et al. Targeted poly(L-glutamic acid)-based hybrid peptosomes co-loaded with doxorubicin and USPIONs as a theranostic platform for metastatic breast cancer. Nanomedicine. 2023 Feb;48:102645. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Poly-L-Glutamic acid (MW 700000) Related Classifications
HY-112111 Related Classifications
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