Poly-L-glutamic acid sodium salt (MW 7500)
Based on 1 Customer Validation
Poly-L-glutamic acid sodium salt (MW 7500) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
For research use only. We do not sell to patients.
- CAS No.: 26247-79-0
- Molecular Weight:7500 (Average)
-
Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-W596474C
Poly-L-glutamic acid sodium salt (MW 15000) -
HY-W596474D
Poly-L-glutamic acid sodium salt (MW 30000) -
HY-W596474A
Poly-L-glutamic acid sodium salt (MW 3000) -
HY-W596474H
Poly-L-glutamic acid sodium salt (MW 60000) -
HY-W596474I
Poly-L-glutamic acid sodium salt (MW 120000) -
HY-W596474E
Poly-L-glutamic acid sodium salt (MW 45000)
All Cathepsin Isoforms
More
Biological Activity
Description
In Vitro
Poly-L-glutamic acid sodium salt acts as a covalent carrier for Paclitaxel (TXL) (HY-B0015) to form PG-TXL (CT-2103)[1].
Poly-L-glutamic acid sodium salt is used to construct targeted hybrid peptosomes co-loaded with Doxorubicin (HY-15142A) and USPIONs as a theranostic platform for metastatic breast cancer[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 26247-79-0
-
Appearance Solid
-
Molecular Weight 7500 (Average)
-
Color White to off-white
-
SMILES
CC(C(CCC(O[Na])=O)NC)=O.[n]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
H2O : 125 mg/mL (Need ultrasonic)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Singer JW, et al. Poly-(L)-glutamic acid-paclitaxel (CT-2103) [XYOTAX], a biodegradable polymeric drug conjugate: characterization, preclinical pharmacology, and preliminary clinical data. Adv Exp Med Biol. 2003;519:81-99. [Content Brief]
[2]. Li C. Poly(L-glutamic acid)--anticancer drug conjugates. Adv Drug Deliv Rev. 2002 Sep 13;54(5):695-713. [Content Brief]
[3]. Hasannia M, et al. Targeted poly(L-glutamic acid)-based hybrid peptosomes co-loaded with doxorubicin and USPIONs as a theranostic platform for metastatic breast cancer. Nanomedicine. 2023 Feb;48:102645. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Poly-L-glutamic acid sodium salt (MW 7500) Related Classifications
HY-W596474B Related Classifications
Powered by Bioz