Poly-L-glutamic acid sodium salt (MW 45000)
Poly-L-glutamic acid sodium salt (MW 45000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
For research use only. We do not sell to patients.
- CAS No.: 26247-79-0
- Molecular Weight:45000 (Average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-W596474C
Poly-L-glutamic acid sodium salt (MW 15000)
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HY-W596474D
Poly-L-glutamic acid sodium salt (MW 30000)
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HY-W596474B
Poly-L-glutamic acid sodium salt (MW 7500)
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HY-W596474A
Poly-L-glutamic acid sodium salt (MW 3000)
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HY-W596474H
Poly-L-glutamic acid sodium salt (MW 60000)
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HY-W596474I
Poly-L-glutamic acid sodium salt (MW 120000)
All Cathepsin Isoforms
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Biological Activity
Poly-L-glutamic acid sodium salt acts as a covalent carrier for Paclitaxel (TXL) (HY-B0015) to form PG-TXL (CT-2103)[1].
Poly-L-glutamic acid sodium salt is used to construct targeted hybrid peptosomes co-loaded with Doxorubicin (HY-15142A) and USPIONs as a theranostic platform for metastatic breast cancer[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 26247-79-0
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Molecular Weight 45000 (Average)
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SMILES
CC(C(CCC(O[Na])=O)NC)=O.[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Singer JW, et al. Poly-(L)-glutamic acid-paclitaxel (CT-2103) [XYOTAX], a biodegradable polymeric drug conjugate: characterization, preclinical pharmacology, and preliminary clinical data. Adv Exp Med Biol. 2003;519:81-99. [Content Brief]
[2]. Li C. Poly(L-glutamic acid)--anticancer drug conjugates. Adv Drug Deliv Rev. 2002 Sep 13;54(5):695-713. [Content Brief]
[3]. Hasannia M, et al. Targeted poly(L-glutamic acid)-based hybrid peptosomes co-loaded with doxorubicin and USPIONs as a theranostic platform for metastatic breast cancer. Nanomedicine. 2023 Feb;48:102645. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Poly-L-glutamic acid sodium salt (MW 45000) Related Classifications
HY-W596474E Related Classifications
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