1. Metabolic Enzyme/Protease
  2. Cathepsin
    Proteasome
  3. Calpeptin

Calpeptin 

Cat. No.: HY-100223 Purity: >98.0%
Handling Instructions

Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets. Calpeptin is also an inhibitor of cathepsin K.

For research use only. We do not sell to patients.

Calpeptin Chemical Structure

Calpeptin Chemical Structure

CAS No. : 117591-20-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 440 In-stock
Estimated Time of Arrival: December 31
200 mg USD 690 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets[1]. Calpeptin is also an inhibitor of cathepsin K[2].

IC50 & Target

ID50: 40 nM (Calpain I in human platelets)[1].
Cthepsin K[2]

In Vitro

Calpeptin (0-100 nM, 24 hours) treatment suppresses the proliferation of both WI38 VA13 and IMR90 cells in a dose-dependent manner. Calpeptin (1000 pg/ml, 24 hours) inhibits IL-6-induced cell proliferation of lung fibroblasts[3].

Cell Proliferation Assay[3]

Cell Line: WI38 VA13 and IMR90 cells
Concentration: 0-100 nM
Incubation Time: 24 hours
Result: Suppressed the proliferation in a dose-dependent manner.
In Vivo

Calpeptin with Bleo (0.04 mg/mouse, i.p., 3 times weekly, 28 days) administration significantly inhibits the collagen deposition and increases of calpain activity in the bleomycin treated mouse lung tissues[3].

Animal Model: C57BL/6 female mice (Eight-week-old)[3].
Dosage: 0.04 mg/mouse.
Administration: Intraperitoneally three times weekly for 28 days (together with Bleo).
Result: Inhibited the collagen deposition and increase of calpain activity in the bleomycin treated mouse lung tissues.
Molecular Weight

362.46

Formula

C₂₀H₃₀N₂O₄

CAS No.

117591-20-5

SMILES

O=C(OCC1=CC=CC=C1)N[[email protected]](C(N[[email protected]](C=O)CCCC)=O)CC(C)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 155 mg/mL (427.63 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7589 mL 13.7946 mL 27.5893 mL
5 mM 0.5518 mL 2.7589 mL 5.5179 mL
10 mM 0.2759 mL 1.3795 mL 2.7589 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Calpeptin
Cat. No.:
HY-100223
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