m-CPBG hydrochloride
Based on 1 publication(s) in Google Scholar
m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.85%
- CAS No.: 2113-05-5
- Formule: C8H11Cl2N5
- Masse moléculaire:248.12
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Stockage:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) m-CPBG hydrochloride
MoreVoir tous les produits spécifiques à Isoform 5-HT Receptor
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Activité biologique
Description
IC50 & Target
[1]|
5-HT3 Receptor |
In Vivo
m-CPBG hydrochloride (third ventricle injection; 160 nM) significantly inhibits water intake in hypovolemic animals[1].
m-CPBG hydrochloride (third ventricle injection; 320 nM) decreases water intake in water-deprived rats[1].
m-CPBG hydrochloride (central administration） inhibits water intake induced by pharmacological activation of central cholinergic and angiotensinergic pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar male rats[1]
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Dosage:80, 160 and 320 nM
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Administration:Ventricle injection
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Result:Decreased water intake induced by water deprivation, acute salt load and hypovolemia.
Chemical Information
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CAS No. 2113-05-5
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Appearance Solid
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Masse moléculaire 248.12
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Formule C8H11Cl2N5
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Color White to off-white
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SMILES
NC(NC(NC1=CC=CC(Cl)=C1)=N)=N.Cl
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Synonyms
1-(3-Chlorophenyl)biguanide hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvant et solubilité
In Vitro:
H2O : 100 mg/mL (403.03 mM; Need ultrasonic)
DMSO : 5.83 mg/mL (23.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.0303 mL | 20.1515 mL | 40.3031 mL | 100.7577 mL |
| 5 mM | 0.8061 mL | 4.0303 mL | 8.0606 mL | 20.1515 mL | |
| 10 mM | 0.4030 mL | 2.0152 mL | 4.0303 mL | 10.0758 mL | |
| 15 mM | 0.2687 mL | 1.3434 mL | 2.6869 mL | 6.7172 mL | |
| 20 mM | 0.2015 mL | 1.0076 mL | 2.0152 mL | 5.0379 mL | |
| H2O | 25 mM | 0.1612 mL | 0.8061 mL | 1.6121 mL | 4.0303 mL |
| 30 mM | 0.1343 mL | 0.6717 mL | 1.3434 mL | 3.3586 mL | |
| 40 mM | 0.1008 mL | 0.5038 mL | 1.0076 mL | 2.5189 mL | |
| 50 mM | 0.0806 mL | 0.4030 mL | 0.8061 mL | 2.0152 mL | |
| 60 mM | 0.0672 mL | 0.3359 mL | 0.6717 mL | 1.6793 mL | |
| 80 mM | 0.0504 mL | 0.2519 mL | 0.5038 mL | 1.2595 mL | |
| 100 mM | 0.0403 mL | 0.2015 mL | 0.4030 mL | 1.0076 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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