2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. m-CPBG hydrochloride

m-CPBG hydrochloride  (Synonyms: 1-(3-Chlorophenyl)biguanide hydrochloride)

Cat. No.: HY-100938 Purity: 99.78%
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m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease.

For research use only. We do not sell to patients.

m-CPBG hydrochloride Chemical Structure

m-CPBG hydrochloride Chemical Structure

CAS No. : 2113-05-5

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Based on 1 publication(s) in Google Scholar

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Description

m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease[1].

In Vivo

m-CPBG hydrochloride (80 and 160 nM) significantly reduces water intake elicited by an acute salt load[1].
m-CPBG hydrochloride (third ventricle injection; 160 nM) significantly inhibits water intake in hypovolemic animals[1].
m-CPBG hydrochloride (third ventricle injection; 320 nM) decreases water intake in water-deprived rats[1].
m-CPBG hydrochloride (central administration） inhibits water intake induced by pharmacological activation of central cholinergic and angiotensinergic pathways[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar male rats[1]
Dosage: 80, 160 and 320 nM
Administration: Ventricle injection
Result: Decreased water intake induced by water deprivation, acute salt load and hypovolemia.
Molecular Weight

248.11

Formula

C8H11Cl2N5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(NC(NC1=CC=CC(Cl)=C1)=N)=N.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (503.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0305 mL 20.1524 mL 40.3047 mL
5 mM 0.8061 mL 4.0305 mL 8.0609 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.0305 mL 20.1524 mL 40.3047 mL 100.7618 mL
5 mM 0.8061 mL 4.0305 mL 8.0609 mL 20.1524 mL
10 mM 0.4030 mL 2.0152 mL 4.0305 mL 10.0762 mL
15 mM 0.2687 mL 1.3435 mL 2.6870 mL 6.7175 mL
20 mM 0.2015 mL 1.0076 mL 2.0152 mL 5.0381 mL
25 mM 0.1612 mL 0.8061 mL 1.6122 mL 4.0305 mL
30 mM 0.1343 mL 0.6717 mL 1.3435 mL 3.3587 mL
40 mM 0.1008 mL 0.5038 mL 1.0076 mL 2.5190 mL
50 mM 0.0806 mL 0.4030 mL 0.8061 mL 2.0152 mL
60 mM 0.0672 mL 0.3359 mL 0.6717 mL 1.6794 mL
80 mM 0.0504 mL 0.2519 mL 0.5038 mL 1.2595 mL
100 mM 0.0403 mL 0.2015 mL 0.4030 mL 1.0076 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-CPBG2113-05-51-(3-Chlorophenyl)biguanide5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT(3)neurological diseasecentral serotonergic systemInhibitorinhibitorinhibit

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