2-Aminonicotinaldehyde 

2-Aminonicotinaldehyde is a synthetic intermediate. 2-Aminonicotinaldehyde can be used for the synthesis of 5-HT3 receptor antagonists, AKT inhibitors, and other compounds. 2-Aminonicotinaldehyde is applicable to research on depression and cancers (including hepatocellular carcinoma)^[1][2][3].

2-Aminonicotinaldehyde can be used for the synthesis of 5-HT3 receptor antagonists, AKT inhibitors, and other agents. 2-Aminonicotinaldehyde is applicable to research on depression and cancers (including hepatocellular carcinoma)^[1][2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

122.13

C₆H₆N₂O

7521-41-7

Solid

Light yellow to yellow

O=CC1=C(N)N=CC=C1

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Mahesh R, et al. Design, synthesis and evaluation of antidepressant activity of novel 2-methoxy 1, 8 naphthyridine 3-carboxamides as 5-HT3 receptor antagonists. Chem Biol Drug Des. 2014;83(5):583-591.  [Content Brief]

  [2]. Zhang Z, et al. Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors. J Med Chem. 2022;65(4):3249-3265.  [Content Brief]

  [3]. Jean-Marc Lapierre, et al. Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor. Journal of Medicinal Chemistry 2016 59 (13), 6455-6469