MCI-225 hydrate hydrochloride
MCI-225 (DDP-225) hydrate hydrochloride is a selective and orally active noradrenaline (NA) reuptake inhibitor with 5-HT3 receptor antagonism. MCI-225 hydrate hydrochloride has antidepressant-like and anxiolytic-like properties. MCI-225 hydrate hydrochloride can be used for the study of anxiety disorder.
For research use only. We do not sell to patients.
- CAS No.: 476148-82-0
- Formula: C17H20ClFN4OS
- Molecular Weight:382.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT3 Receptor |
In the Morris-type water maze task in rats, MCI-225 (1-10 mg/kg, PO) hydrate hydrochloride reduces the spatial learning impairment induced by Scopolamine (HY-N0296) (0.5 mg/kg, IP)[2].
In a passive avoidance (PA) task in rats, administration of MCI-225 hydrate hydrochloride prior to training (1-30 mg/kg, PO) hydrate hydrochloride lessenes the carbon dioxide (CO2)-induced amnesia in a dose-dependent manner[2].
MCI-225 (1-100 mg/kg) hydrate hydrochloride does not affect gross behavior in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 476148-82-0
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Molecular Weight 382.88
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Formula C17H20ClFN4OS
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SMILES
CC1=CC2=C(N=C(N=C2S1)N3CCNCC3)C4=CC=CC=C4F.Cl.O
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Synonyms
DDP-225 hydrate hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Eguchi J, et al. The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism. Pharmacol Biochem Behav. 2001 Apr;68(4):677-83. [Content Brief]
[2]. Eguchi J, et al. Effects of a novel compound MCI-225 on impaired learning and memory in rats. Pharmacol Biochem Behav. 1994 Jun;48(2):345-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MCI-225 hydrate hydrochloride Related Classifications
HY-120810 Related Classifications
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