5-HT6R antagonist 3
5-HT6R antagonist 3 (compound 15) is a potent, selective and brain-penetrant 5-HT6R antagonist with Ki values of 14 nM, 3533 nM, 35 nM, 1449 nM for 5-HT6, 5-HT1A, 5-HT2A, 5-HT7, respectively. 5-HT6R antagonist 3 shows anxiolytic-like and properties neuroprotective and procognitive-like effects. 5-HT6R antagonist 3 has the potential for the research of Alzheimer’s Disease.
For research use only. We do not sell to patients.
- CAS No.: 3032413-90-1
- Formula: C21H26N6Se
- Molecular Weight:441.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
|
5-HT1A Receptor |
5-HT2A Receptor |
5-HT7 Receptor |
5-HT6 Receptor 14 nM (Ki) |
5-HT1A Receptor 3533 nM (Ki) |
5-HT2A Receptor 35 nM (Ki) |
5-HT7 Receptor 1449 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SH-SY5Y | IC50 |
53.2 μM
Compound: 15
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Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 27 hrs by MTS assay
Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 27 hrs by MTS assay
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[PMID: 38190615] |
Chemical Information
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CAS No. 3032413-90-1
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Molecular Weight 441.43
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Formula C21H26N6Se
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SMILES
CC(C)([Se]C1=CC2=C(C=C1)C=CC=C2)C3=NC(N4CCN(CC4)C)=NC(N)=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-HT6R antagonist 3 Related Classifications
HY-163150 Related Classifications
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