3032413-90-1
3032413-90-1
Chemical Structure
5-HT6R antagonist 3
- CAS No.: 3032413-90-1
- Formula:C21H26N6Se
- Molecular Weight:441.43
InChIKey: AZEGGJUBCUBYAM-UHFFFAOYSA-N
SMILES: CC(C)([Se]C1=CC2=C(C=C1)C=CC=C2)C3=NC(N4CCN(CC4)C)=NC(N)=N3
Biological Activity: 5-HT6R antagonist 3 (compound 15) is a potent, selective and brain-penetrant 5-HT6R antagonist with Ki values of 14 nM, 3533 nM, 35 nM, 1449 nM for 5-HT6, 5-HT1A, 5-HT2A, 5-HT7, respectively. 5-HT6R antagonist 3 shows anxiolytic-like and properties neuroprotective and procognitive-like effects. 5-HT6R antagonist 3 has the potential for the research of Alzheimer’s Disease[1].
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5-HT6R antagonist 3 | 5-HT6R antagonist 3 (compound 15) is a potent, selective and brain-penetrant 5-HT6R antagonist with Ki values of 14 nM, 3533 nM, 35 nM, 1449 nM for 5-HT6, 5-HT1A, 5-HT2A, 5-HT7, respectively. 5-HT6R antagonist 3 shows anxiolytic-like and properties neuroprotective and procognitive-like effects. 5-HT6R antagonist 3 has the potential for the research of Alzheimer’s Disease. | |||||||||||||||||||||
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References
Keywords
