2. GPCR/G Protein
    Neuronal Signaling
  3. 5-HT Receptor
  4. SB 258719

SB 258719 

Cat. No.: HY-U00443 Purity: 99.04%
COA Handling Instructions

SB 258719 is a selective 5-HT7 receptor antagonist with high affinity (pKi=7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease.

For research use only. We do not sell to patients.

SB 258719 Chemical Structure

SB 258719 Chemical Structure

CAS No. : 195199-95-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 149 In-stock
Liquid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 149 In-stock
Liquid
5 mg USD 135 In-stock
10 mg USD 216 In-stock
25 mg USD 432 In-stock
50 mg USD 690 In-stock
100 mg USD 1100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Other Forms of SB 258719:

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SB 258719 is a selective 5-HT7 receptor antagonist with high affinity (pKi=7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease[1][2][3].

IC50 & Target

5-HT7 Receptor

7.5 (pKi)

In Vitro

SB 258719 (1, 3 and 10 μM; HEK 293 cells) produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

SB 258719 (5-20 mg/kg; i.p.) significantly attenuates the 5-CT-induced hypothermia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss Webster mice (20-25 g)[2].
Dosage: 5-20 mg/kg
Administration: I.p.
Result: Significantly attenuated the 5-CT-induced hypothermia.
Molecular Weight

338.51

Appearance

Liquid

Formula

C18H30N2O2S
CAS No.
SMILES

O=S(C1=CC=CC(C)=C1)(N(C)[[email protected]](C)CCN2CCC(C)CC2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (738.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9541 mL 14.7706 mL 29.5412 mL
5 mM 0.5908 mL 2.9541 mL 5.9082 mL
10 mM 0.2954 mL 1.4771 mL 2.9541 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (18.46 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (18.46 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (18.46 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.04%

COA (245 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SB 258719195199-95-2SB258719SB-2587195-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorselectiveaffinityhydrochlorideapparentpartialinverseagonismInhibitorinhibitorinhibit

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