SB 258719 hydrochloride
Based on 1 publication(s) in Google Scholar
SB 258719 hydrochloride is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 hydrochloride can be used for the research of cancer and neurological diseases.
For research use only. We do not sell to patients.
- CAS No.: 1217674-10-6
- Formula: C18H31ClN2O2S
- Molecular Weight:374.97
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SB 258719 hydrochloride
MoreAll 5-HT Receptor Isoforms
More
Biological Activity
|
5-HT7 Receptor |
5-HT7 Receptor 7.5 (pKi) |
SB-258719 (1, 3 and 10 μM; HEK 293 cells) hydrochloride produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Swiss Webster mice (20~25 g)[2].
-
Dosage:5~20 mg/kg
-
Administration:I.p.
-
Result:Significantly attenuated the 5-CT-induced hypothermia.
Chemical Information
-
CAS No. 1217674-10-6
-
Molecular Weight 374.97
-
Formula C18H31ClN2O2S
-
SMILES
O=S(C1=CC=CC(C)=C1)(N(C)[C@H](C)CCN2CCC(C)CC2)=O.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Neurosci Bull
Brain Serotonin Deficiency Impairs Ovarian Reserve Function via the Hypothalamic-Pituitary-Ovarian Axis. [Abstract]2026 May 25. PMID: 42184065
Purity & Documentation
References
[1]. Thomas DR, et al. Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719. Br J Pharmacol. 1998;124(6):1300-1306. [Content Brief]
[2]. Guscott MR, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003;44(8):1031-1037. [Content Brief]
[3]. Fatima S, et al. 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin. Mol Oncol. 2016;10(2):195-212. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SB 258719 hydrochloride Related Classifications
HY-103123 Related Classifications
Powered by Bioz