1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. SB 258719 hydrochloride

SB 258719 hydrochloride 

Cat. No.: HY-103123
Handling Instructions

SB 258719 (hydrochloride) is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 (hydrochloride) can be used for the research of cancer and neurological diseases.

For research use only. We do not sell to patients.

SB 258719 hydrochloride Chemical Structure

SB 258719 hydrochloride Chemical Structure

CAS No. : 1217674-10-6

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Description

SB 258719 (hydrochloride) is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 (hydrochloride) can be used for the research of cancer and neurological diseases[1][2].

IC50 & Target[1]

5-HT7 Receptor

7.5 (pKi)

In Vitro

SB-258719 (1, 3 and 10 μM; HEK 293 cells) (hydrochloride) produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB-258719 (5~20 mg/kg; i.p.) (hydrochloride) significantly attenuates the 5-CT-induced hypothermia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss Webster mice (20~25 g)[2].
Dosage: 5~20 mg/kg
Administration: I.p.
Result: Significantly attenuated the 5-CT-induced hypothermia.
Molecular Weight

374.97

Formula

C₁₈H₃₁ClN₂O₂S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
SB 258719 hydrochloride
Cat. No.:
HY-103123
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