1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Dihydroergotamine mesylate

Dihydroergotamine mesylate 

Cat. No.: HY-B0670A Purity: 99.91%
Handling Instructions

Dihydroergotamine mesylate is an ergot alkaloid used to treat migraines.

For research use only. We do not sell to patients.

Dihydroergotamine mesylate Chemical Structure

Dihydroergotamine mesylate Chemical Structure

CAS No. : 6190-39-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 70 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Dihydroergotamine mesylate is an ergot alkaloid used to treat migraines. Target: 5-HT Receptors Dihydroergotamine is not as effective as sumatriptan or phenothiazines as a single agent for treatment of acute migraine headache; however, when administered with an antiemetic, dihydroergotamine appears to be as effective as opiates, ketorolac, or valproate. Given its nonnarcotic properties, parenteral dihydroergotamine combined with an antiemetic should be considered as effective initial therapy in clinical practice [1]. The introduction of the intranasal formulation of DHE provides both pharmacologic and patient-convenience advantages for use in migraine therapy [2, 3].

Clinical Trial
Molecular Weight

679.78

Formula

C₃₄H₄₁N₅O₈S

CAS No.

6190-39-2

SMILES

O[[email protected]@]([[email protected]@](CCC1)([H])N1C2=O)(O[[email protected]](NC([[email protected]@H](CN(C)[[email protected]]3([H])C4)C[[email protected]]3([H])C5=C6C4=CNC6=CC=C5)=O)(C)C7=O)N7[[email protected]]2CC8=CC=CC=C8.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (73.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4711 mL 7.3553 mL 14.7106 mL
5 mM 0.2942 mL 1.4711 mL 2.9421 mL
10 mM 0.1471 mL 0.7355 mL 1.4711 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.68 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.68 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.68 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.91%

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Keywords:

Dihydroergotamine5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Dihydroergotamine mesylate
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HY-B0670A
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