LY215840
LY215840, a 5-HT7 receptor ligand and a 5-HT2 receptor antagonist, blocks serotonin-induced relaxation in canine coronary artery.
For research use only. We do not sell to patients.
- CAS No.: 137328-52-0
- Formula: C24H33N3O2
- Molecular Weight:395.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT2 Receptor |
5-HT7 Receptor |
LY215840 (1 μM) markedly potentiated contraction to 5-carboxamidotryptamine, the most potent coronary relaxant agonist and the agonist with the highest 5-HT7 receptor affinity[1].
LY215840 (3 x 10-10 to 10-8 M) blocks 5-HT2 receptors mediating contraction to 5-HT in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 137328-52-0
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Molecular Weight 395.54
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Formula C24H33N3O2
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SMILES
CC(N1C2=CC=CC3=C2C(C[C@]4([H])[C@]3([H])C[C@@H](C(N[C@@H]5[C@@H](CCC5)O)=O)CN4C)=C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. D J Cushing, et al. LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery. J Pharmacol Exp Ther. 1996 Jun;277(3):1560-6. [Content Brief]
[2]. M L Cohen , et al. LY215840, a potent 5-hydroxytryptamine (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2 receptors and delays occlusion in a rabbit model of thrombosis. J Pharmacol Exp Ther. 1992 Apr;261(1):202-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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