137328-52-0
137328-52-0
Chemical Structure
LY215840
- CAS No.: 137328-52-0
- Formula:C24H33N3O2
- Molecular Weight:395.54
IUPAC Name: (6aR,9R,10aR)-N-((1S,2R)-2-hydroxycyclopentyl)-4-isopropyl-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
InChIKey: IMSDOBUYDTVEHN-ILMFXRJHSA-N
SMILES: CC(N1C2=CC=CC3=C2C(C[C@]4([H])[C@]3([H])C[C@@H](C(N[C@@H]5[C@@H](CCC5)O)=O)CN4C)=C1)C
Biological Activity: LY215840, a 5-HT7 receptor ligand and a 5-HT2 receptor antagonist, blocks serotonin-induced relaxation in canine coronary artery[1][2].
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LY215840 | LY215840, a 5-HT7 receptor ligand and a 5-HT2 receptor antagonist, blocks serotonin-induced relaxation in canine coronary artery. | |||||||||||||||||||||
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References
- [1]. D J Cushing, et al. LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery. J Pharmacol Exp Ther. 1996 Jun;277(3):1560-6. [Content Brief]
- [2]. M L Cohen , et al. LY215840, a potent 5-hydroxytryptamine (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2 receptors and delays occlusion in a rabbit model of thrombosis. J Pharmacol Exp Ther. 1992 Apr;261(1):202-8. [Content Brief]
