442-51-3
442-51-3
Chemical Structure
Harmine
Synonym(s): Telepathine
- CAS. Nr.: 442-51-3
- Formula:C13H12N2O
- Molecular Weight:212.25
IUPAC Name: 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
InChIKey: BXNJHAXVSOCGBA-UHFFFAOYSA-N
SMILES: CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3
Biological Activity: Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Harmine | 99.97% | Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM. | ||||||||||||||||||||
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Harmine (GMP) | Harmine (GMP) (Telepathine (GMP)) is Harmine (HY-N0737A) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM. | |||||||||||||||||||||
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Harmine (Standard) | 99.83% | Harmine (Standard) is the analytical standard of Harmine. This product is intended for research and analytical applications. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM. | ||||||||||||||||||||
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Harmine-d3 | 99.03% | Harmine-d3 (Telepathine-d3) is the deuterium labeled Harmine. Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM. | ||||||||||||||||||||
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Harmol hydrochloride | Harmol hydrochloride is an orally active β-carboline alkaloid. Harmol hydrochloride is a TFEB activator and monoamine oxidase inhibitor. Harmol hydrochloride can induce cell mitosis, Autophagy and Apoptosis. Harmol hydrochloride promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol hydrochloride has anti-tumor, anti-depressant and anti-aging activities. Harmol hydrochloride improves motor impairment in a mouse Parkinson's disease model. | |||||||||||||||||||||
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AnnH31 | 99.91% | AnnH31 is a Dyrk1A inhibitor (IC50: 81 nM). AnnH31 also inhibits MAO-A with an IC50 of 3.2 μM. AnnH31 inhibits cell viability of HeLa, PC12 and SH-SY5Y cells. | ||||||||||||||||||||
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STING agonist-14 | 98.41% | STING agonist-14 (compound 12b) is a potent STING agonist that is efficacious across species. STING agonist-14 could activate the pathway by directly binding human STING. STING agonist-14 can be used for the research of tumours or viral infections. | ||||||||||||||||||||
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Dyrk1A-IN-8 | Dyrk1A-IN-8 (compound 4C) is a potent inhibitor of Dyrk1A , with the IC50 of 209 nM. Dyrk1A-IN-8 plays an important role in neurodegenerative diseases. | |||||||||||||||||||||
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Harmine hydrochloride (Standard) | ≥98% | Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM. | ||||||||||||||||||||
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1-Methoxymethyl-β-carboline | 1-Methoxymethyl-β-carboline is a natural product isolated from the root of Eurycoma longifolia. | |||||||||||||||||||||
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7-Hydroxy-1-methoxy-3-methylcarbazole | 7-Hydroxy-1-methoxy-3-methylcarbazole is a natural product. | |||||||||||||||||||||
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Clauszoline K | Clauszoline K is a natural alkaloid. | |||||||||||||||||||||
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7-Methoxy-β-carboline-1-propionic acid | 7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia. | |||||||||||||||||||||
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1-Acetyl-β-carboline | 97.04% | 1-Acetyl-β-carboline is a metabolite of Streptomyces kasugaensis and antibacterial agent. 1-Acetyl-β-carboline increases tyrosinase activity, reduces ERK phosphorylation. 1-Acetyl-β-carboline exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranging from 128 to 256 ug/mL. 1-Acetyl-β-carboline increases the melanin. | ||||||||||||||||||||
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